Synthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes

A series of hydrazone and 3-nitrovinyl analogs of indole-3-carboxaldehydes and related compounds were synthesized and screened for antitubercular activity against Mycobacterium tuberculosis H37RV in BACTEC 12B medium using the Microplate Alamar Blue Assay (MABA). Several compounds showed inhibitory...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2009-02, Vol.24 (1), p.117-124
Hauptverfasser:	Sonar, Vijayakumar N., Crooks, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-nitrovinylindoles Aldehydes - chemistry antitubercular activity Antitubercular Agents - chemical synthesis benzo[b]thiophene-3-hydrazones Dose-Response Relationship, Drug Hydrazones - chemical synthesis Hydrazones - pharmacology Indole-3-hydrazones Inhibitory Concentration 50 Microbial Sensitivity Tests Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects thiophene-3-hydrazones Vinyl Compounds - chemical synthesis Vinyl Compounds - pharmacology
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