Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression

TAK1 (transforming growth factor-beta-activated kinase 1), a mitogen-activated protein kinase kinase kinase, is activated by various cytokines, including interleukin-1 (IL-1). However, the precise regulation for TAK1 activation at the molecular level is still not fully understood. Here we report tha...

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Veröffentlicht in:	The Journal of biological chemistry 2008-09, Vol.283 (36), p.24497
Hauptverfasser:	Yu, Yang, Ge, Ningling, Xie, Min, Sun, Wenjing, Burlingame, Susan, Pass, Amy K, Nuchtern, Jed G, Zhang, Dekai, Fu, Songbin, Schneider, Michael D, Fan, Jia, Yang, Jianhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Fibroblasts - cytology Fibroblasts - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - physiology HeLa Cells Humans Interleukin-1 - pharmacology Interleukin-6 - biosynthesis Interleukin-6 - genetics MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism Mice Mice, Knockout Mutation, Missense NF-kappa B - genetics NF-kappa B - metabolism Phosphorylation - drug effects Protein Structure, Secondary Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism
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