Effect of Subcutaneous Injection and Oral Voluntary Ingestion of Buprenorphine on Post-Operative Serum Corticosterone Levels in Male Rats
Background: Adequate peri-operative analgesia may reduce post-operative stress response and improve recovery in laboratory animals. We have established a method involving repeated automated blood sampling, allowing quantification of serum corticosterone levels in rats for stress assessment without s...
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| Veröffentlicht in: | European surgical research 2008-01, Vol.41 (3), p.272-278 |
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| description | Background: Adequate peri-operative analgesia may reduce post-operative stress response and improve recovery in laboratory animals. We have established a method involving repeated automated blood sampling, allowing quantification of serum corticosterone levels in rats for stress assessment without stress-inducing handling or restraint. In the present study, the effects of the commonly used route of buprenorphine administration (0.05 mg/kg injected subcutaneously) were compared with oral administration (0.4 mg/kg mixed with Nutella® and orally administered by voluntary ingestion) in male Sprague-Dawley rats. Methods: A catheter was placed in the jugular vein and attached to an Accusampler® for automated blood sampling. During 96 h after surgery, blood was collected at specified time points. Pre- and post-operative body weights and water consumption were registered. Results: Buprenorphine significantly suppressed levels of circulating corticosterone after the oral but not after the subcutaneous treatment. Both buprenorphine treatments had a positive impact on maintenance of body weight and water consumption, compared to the control group that received no buprenorphine. Conclusion: The present investigation suggests that oral voluntary ingestion ad libitum is an efficacious, convenient and non-invasive way of administering peri-operative buprenorphine to rats, as judged by corticosteroid response and effects on body weight and water consumption. |
| doi_str_mv | 10.1159/000142372 |
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We have established a method involving repeated automated blood sampling, allowing quantification of serum corticosterone levels in rats for stress assessment without stress-inducing handling or restraint. In the present study, the effects of the commonly used route of buprenorphine administration (0.05 mg/kg injected subcutaneously) were compared with oral administration (0.4 mg/kg mixed with Nutella® and orally administered by voluntary ingestion) in male Sprague-Dawley rats. Methods: A catheter was placed in the jugular vein and attached to an Accusampler® for automated blood sampling. During 96 h after surgery, blood was collected at specified time points. Pre- and post-operative body weights and water consumption were registered. Results: Buprenorphine significantly suppressed levels of circulating corticosterone after the oral but not after the subcutaneous treatment. Both buprenorphine treatments had a positive impact on maintenance of body weight and water consumption, compared to the control group that received no buprenorphine. Conclusion: The present investigation suggests that oral voluntary ingestion ad libitum is an efficacious, convenient and non-invasive way of administering peri-operative buprenorphine to rats, as judged by corticosteroid response and effects on body weight and water consumption.</description><identifier>ISSN: 0014-312X</identifier><identifier>ISSN: 1421-9921</identifier><identifier>EISSN: 1421-9921</identifier><identifier>DOI: 10.1159/000142372</identifier><identifier>PMID: 18596376</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Administration, Oral ; Analgesia ; Analgesia - methods ; Analgesics, Opioid - administration & dosage ; Animals ; Body Weight - drug effects ; Buprenorphine - administration & dosage ; Corticosterone - blood ; Drinking - drug effects ; Injections, Subcutaneous ; Male ; MEDICIN ; MEDICINE ; Original Paper ; Postoperative Period ; Rats ; Rats, Sprague-Dawley ; Self Administration ; Stress, Physiological - drug effects ; Surgical stress</subject><ispartof>European surgical research, 2008-01, Vol.41 (3), p.272-278</ispartof><rights>2008 S. Karger AG, Basel</rights><rights>Copyright 2008 S. Karger AG, Basel.</rights><rights>Copyright (c) 2008 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-2a7bcf864635e7c55a98f91e12c4864b95f15ed8fa0c6e0688c043c342d683a53</citedby><cites>FETCH-LOGICAL-c394t-2a7bcf864635e7c55a98f91e12c4864b95f15ed8fa0c6e0688c043c342d683a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,2430,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18596376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-102299$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldkuhl, R.</creatorcontrib><creatorcontrib>Carlsson, H.-E.</creatorcontrib><creatorcontrib>Hau, J.</creatorcontrib><creatorcontrib>Abelson, K.S.P.</creatorcontrib><title>Effect of Subcutaneous Injection and Oral Voluntary Ingestion of Buprenorphine on Post-Operative Serum Corticosterone Levels in Male Rats</title><title>European surgical research</title><addtitle>Eur Surg Res</addtitle><description>Background: Adequate peri-operative analgesia may reduce post-operative stress response and improve recovery in laboratory animals. We have established a method involving repeated automated blood sampling, allowing quantification of serum corticosterone levels in rats for stress assessment without stress-inducing handling or restraint. In the present study, the effects of the commonly used route of buprenorphine administration (0.05 mg/kg injected subcutaneously) were compared with oral administration (0.4 mg/kg mixed with Nutella® and orally administered by voluntary ingestion) in male Sprague-Dawley rats. Methods: A catheter was placed in the jugular vein and attached to an Accusampler® for automated blood sampling. During 96 h after surgery, blood was collected at specified time points. Pre- and post-operative body weights and water consumption were registered. Results: Buprenorphine significantly suppressed levels of circulating corticosterone after the oral but not after the subcutaneous treatment. Both buprenorphine treatments had a positive impact on maintenance of body weight and water consumption, compared to the control group that received no buprenorphine. Conclusion: The present investigation suggests that oral voluntary ingestion ad libitum is an efficacious, convenient and non-invasive way of administering peri-operative buprenorphine to rats, as judged by corticosteroid response and effects on body weight and water consumption.</description><subject>Administration, Oral</subject><subject>Analgesia</subject><subject>Analgesia - methods</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Buprenorphine - administration & dosage</subject><subject>Corticosterone - blood</subject><subject>Drinking - drug effects</subject><subject>Injections, Subcutaneous</subject><subject>Male</subject><subject>MEDICIN</subject><subject>MEDICINE</subject><subject>Original Paper</subject><subject>Postoperative Period</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Self Administration</subject><subject>Stress, Physiological - drug effects</subject><subject>Surgical stress</subject><issn>0014-312X</issn><issn>1421-9921</issn><issn>1421-9921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkV9rFDEUxYModlt98F0kIAiCo_kzyUwe67ZqYWXFavEtZLJ31llnJ2MyqfgR_NbeOksLPiU593fv5eQQ8oSz15wr84YxxkshK3GPLPDCC2MEv08WN3Ihufh2RI5T2uFTmco8JEe8VkbLSi_In_O2BT_R0NLL3Pg8uQFCTvRi2KHchYG6YUPX0fX0KvR5mFz8jcUtpH9FbHubxwhDiOP3bgCK2qeQpmI9QnRTdw30EmLe02WIU-exAjEgtoJr6BPtBvrR9UA_uyk9Ig9a1yd4fDhPyNd351-WH4rV-v3F8nRVeGnKqRCuanxb61JLBZVXypm6NRy48CWqjVEtV7CpW8e8Bqbr2rNSelmKja6lU_KEvJrnpl8w5saOsdujKRtcZ8-6q1Mb4tbmbDkTwhjEX8z4GMPPjLbtvkse-n7-KKuNVlwKhuDz_8BdyHFAKzhKG8Q010i9nCkfQ0oR2tv9nNmbMO1tmMg-O0zMzR42d-QhPQSezsAPF7cQ74C5_y9iEKOE</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Goldkuhl, R.</creator><creator>Carlsson, H.-E.</creator><creator>Hau, J.</creator><creator>Abelson, K.S.P.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope></search><sort><creationdate>20080101</creationdate><title>Effect of Subcutaneous Injection and Oral Voluntary Ingestion of Buprenorphine on Post-Operative Serum Corticosterone Levels in Male Rats</title><author>Goldkuhl, R. ; Carlsson, H.-E. ; Hau, J. ; Abelson, K.S.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-2a7bcf864635e7c55a98f91e12c4864b95f15ed8fa0c6e0688c043c342d683a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Oral</topic><topic>Analgesia</topic><topic>Analgesia - methods</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Buprenorphine - administration & dosage</topic><topic>Corticosterone - blood</topic><topic>Drinking - drug effects</topic><topic>Injections, Subcutaneous</topic><topic>Male</topic><topic>MEDICIN</topic><topic>MEDICINE</topic><topic>Original Paper</topic><topic>Postoperative Period</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Self Administration</topic><topic>Stress, Physiological - drug effects</topic><topic>Surgical stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldkuhl, R.</creatorcontrib><creatorcontrib>Carlsson, H.-E.</creatorcontrib><creatorcontrib>Hau, J.</creatorcontrib><creatorcontrib>Abelson, K.S.P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Proquest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>European surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goldkuhl, R.</au><au>Carlsson, H.-E.</au><au>Hau, J.</au><au>Abelson, K.S.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Subcutaneous Injection and Oral Voluntary Ingestion of Buprenorphine on Post-Operative Serum Corticosterone Levels in Male Rats</atitle><jtitle>European surgical research</jtitle><addtitle>Eur Surg Res</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>41</volume><issue>3</issue><spage>272</spage><epage>278</epage><pages>272-278</pages><issn>0014-312X</issn><issn>1421-9921</issn><eissn>1421-9921</eissn><abstract>Background: Adequate peri-operative analgesia may reduce post-operative stress response and improve recovery in laboratory animals. We have established a method involving repeated automated blood sampling, allowing quantification of serum corticosterone levels in rats for stress assessment without stress-inducing handling or restraint. In the present study, the effects of the commonly used route of buprenorphine administration (0.05 mg/kg injected subcutaneously) were compared with oral administration (0.4 mg/kg mixed with Nutella® and orally administered by voluntary ingestion) in male Sprague-Dawley rats. Methods: A catheter was placed in the jugular vein and attached to an Accusampler® for automated blood sampling. During 96 h after surgery, blood was collected at specified time points. Pre- and post-operative body weights and water consumption were registered. Results: Buprenorphine significantly suppressed levels of circulating corticosterone after the oral but not after the subcutaneous treatment. Both buprenorphine treatments had a positive impact on maintenance of body weight and water consumption, compared to the control group that received no buprenorphine. Conclusion: The present investigation suggests that oral voluntary ingestion ad libitum is an efficacious, convenient and non-invasive way of administering peri-operative buprenorphine to rats, as judged by corticosteroid response and effects on body weight and water consumption.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>18596376</pmid><doi>10.1159/000142372</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0014-312X |
| ispartof | European surgical research, 2008-01, Vol.41 (3), p.272-278 |
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| language | eng |
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| subjects | Administration, Oral Analgesia Analgesia - methods Analgesics, Opioid - administration & dosage Animals Body Weight - drug effects Buprenorphine - administration & dosage Corticosterone - blood Drinking - drug effects Injections, Subcutaneous Male MEDICIN MEDICINE Original Paper Postoperative Period Rats Rats, Sprague-Dawley Self Administration Stress, Physiological - drug effects Surgical stress |
| title | Effect of Subcutaneous Injection and Oral Voluntary Ingestion of Buprenorphine on Post-Operative Serum Corticosterone Levels in Male Rats |
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