Effect of Amorphous Content on Dissolution Characteristics of Rifampicin

Rifampicin, one of the main first line anti-TB drugs, shows variable bioavailability in different marketed preparations and reasons cited include physiological, degradation, manufacturing processing, solid state, and bioavailability assessment procedure. Although the amorphous form of a drug is expe...

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Veröffentlicht in:	Drug development and industrial pharmacy 2008-01, Vol.34 (6), p.642-649
Hauptverfasser:	Panchagnula, Ramesh, Bhardwaj, Vivekanand
Format:	Artikel
Sprache:	eng
Schlagworte:	amorphous Antibiotics, Antitubercular - chemistry Biological and medical sciences Biological Availability Calorimetry, Differential Scanning Crystallization General pharmacology intrinsic dissolution rate Kinetics Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powders rifampicin Rifampin - chemistry solid-state characterization Solubility Spectroscopy, Fourier Transform Infrared Thermogravimetry
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