Promoter methylation of O(6)-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53

Methylation of the O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter is associated with G:C to A:T transitions in the p53 gene in various human cancers, including lung cancer. In tumors with p53 mutation, MGMT promoter methylation is more common in advanced tumors than in early tumors. Howeve...

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Veröffentlicht in:	DNA repair 2008-08, Vol.7 (8), p.1352
Hauptverfasser:	Lai, Ji-Ching, Cheng, Ya-Wen, Goan, Yih-Gang, Chang, Jinghua Tsai, Wu, Tzu-Chin, Chen, Chih-Yi, Lee, Huei
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methylation DNA Modification Methylases - genetics DNA Primers DNA Repair Enzymes - genetics Histone Deacetylase 1 Histone Deacetylases - genetics Humans Lung Neoplasms - enzymology Mutagenesis, Site-Directed Promoter Regions, Genetic Tumor Suppressor Protein p53 - physiology Tumor Suppressor Proteins - genetics
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