Frequency and spectrum of ENU-induced mutation in the ΦX174 transgene in mouse splenic lymphocytes and their significance to spontaneous transgenic rodent mutation frequencies

A perceived disadvantage of transgenic rodent mutation assays is that spontaneous mutant frequencies are high compared to those of endogenous genes and may consequently reduce sensitivity to induced mutation. We have previously argued that unrepaired G:T mismatches from spontaneous deamination of 5-...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mutagenesis 2008-09, Vol.23 (5), p.383-397
Hauptverfasser: Valentine, Carrie R., Rainey, Heather F., Farrell, Jessica M., Shaddock, Joseph G., Dobrovolsky, Vasily N., Delongchamp, Robert R.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!