Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks

p53 and p19(ARF) are tumor suppressors frequently mutated in human tumors. In a high-throughput screen in mice for mutations collaborating with either p53 or p19(ARF) deficiency, we identified 10,806 retroviral insertion sites, implicating over 300 loci in tumorigenesis. This dataset reveals 20 gene...

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Veröffentlicht in:	Cell 2008-05, Vol.133 (4), p.727
Hauptverfasser:	Uren, Anthony G, Kool, Jaap, Matentzoglu, Konstantin, de Ridder, Jeroen, Mattison, Jenny, van Uitert, Miranda, Lagcher, Wendy, Sie, Daoud, Tanger, Ellen, Cox, Tony, Reinders, Marcel, Hubbard, Tim J, Rogers, Jane, Jonkers, Jos, Wessels, Lodewyk, Adams, David J, van Lohuizen, Maarten, Berns, Anton
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cloning, Molecular Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Gene Regulatory Networks Genes, p53 Genes, Tumor Suppressor Genomics - methods Humans Mice Mice, Knockout Mutagenesis, Insertional Neoplasms - genetics Neoplasms - metabolism Sequence Analysis, DNA Tumor Suppressor Protein p53 - metabolism
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