EGFR Mutations in Lung Adenocarcinomas: Clinical Testing Experience and Relationship to EGFR Gene Copy Number and Immunohistochemical Expression

Lung adenocarcinomas responsive to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors possess EGFR mutations and often increased EGFR copy number. We prospectively studied 334 clinical cases using polymerase chain reaction-based assays to detect deletions within exon 19 and the L858R...

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Veröffentlicht in:	The Journal of molecular diagnostics : JMD 2008-05, Vol.10 (3), p.242
Hauptverfasser:	Li, Allan R, Chitale, Dhananjay, Riely, Gregory J, Pao, William, Miller, Vincent A, Zakowski, Maureen F, Rusch, Valerie, Kris, Mark G, Ladanyi, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology DNA Mutational Analysis Gene Amplification Genes, erbB-1 Humans In Situ Hybridization Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mutation Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Tissue Array Analysis
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