Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca2+ Channel Regulation in Adult Rat Ventricular Myocytes: Role of Phosphodiesterases

Steady-state activation of cardiac β-adrenergic receptors leads to an intracellular compartmentation of cAMP resulting from localized cyclic nucleotide phosphodiesterase (PDE) activity. To evaluate the time course of the cAMP changes in the different compartments, brief (15 seconds) pulses of isopre...

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Veröffentlicht in:	Circulation research 2008-05, Vol.102 (9), p.1091-1100
Hauptverfasser:	Leroy, Jérôme, Abi-Gerges, Aniella, Nikolaev, Viacheslav O, Richter, Wito, Lechêne, Patrick, Mazet, Jean-Luc, Conti, Marco, Fischmeister, Rodolphe, Vandecasteele, Grégoire
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology Adrenergic beta-Agonists - pharmacology Animals Biological and medical sciences Biosensing Techniques Calcium Channels, L-Type - metabolism Cells, Cultured Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism Cyclic Nucleotide-Gated Cation Channels - genetics Cyclic Nucleotide-Gated Cation Channels - metabolism Cytosol - metabolism Dose-Response Relationship, Drug Enzyme Activation Fluorescence Resonance Energy Transfer Fundamental and applied biological sciences. Psychology Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Heart Ventricles - metabolism Isoproterenol - pharmacology Kinetics Male Membrane Potentials Microscopy, Fluorescence - methods Myocardial Contraction - drug effects Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - metabolism Phosphodiesterase 3 Inhibitors Phosphodiesterase 4 Inhibitors Phosphodiesterase Inhibitors - pharmacology Phosphorylation Quinolones - pharmacology Rats Rats, Wistar Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - metabolism Sarcolemma - metabolism Signal Transduction - drug effects Transfection Vertebrates: cardiovascular system
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