Stem cells and enhanced healing of chronic tympanic membrane perforation
Conclusions. Important information about the basic reparative process of tympanic membrane (TM) healing is shown, which can be incorporated for further clinical understanding. This provides a basis for the exploration of stem cell treatment for TM perforations and holds promise for future improvemen...
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| Veröffentlicht in: | Acta oto-laryngologica 2008-01, Vol.128 (4), p.352-359 |
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| creator | Rahman, Anisur Olivius, Petri Dirckx, Joris Von Unge, Magnus Hultcrantz, Malou |
| description | Conclusions. Important information about the basic reparative process of tympanic membrane (TM) healing is shown, which can be incorporated for further clinical understanding. This provides a basis for the exploration of stem cell treatment for TM perforations and holds promise for future improvements. Objectives. This study aimed to analyse the healing of TM perforation by using stem cells and the stiffness of the membrane was tested in an acute and long-term study. Materials and methods. Sprague-Dawley rats were used in a model of TM perforation. The perforation was performed with a laser system. Stem cells were applied and the healing time and morphological analysis were performed with light and transmission electron microscope. Stiffness was examined by moiré interferometry. Results. The stiffness of the perforated and healed TM was restored after just 2 weeks. In the chronic perforation model, mesenchymal stem cells enhanced the healing. |
| doi_str_mv | 10.1080/00016480701762508 |
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Important information about the basic reparative process of tympanic membrane (TM) healing is shown, which can be incorporated for further clinical understanding. This provides a basis for the exploration of stem cell treatment for TM perforations and holds promise for future improvements. Objectives. This study aimed to analyse the healing of TM perforation by using stem cells and the stiffness of the membrane was tested in an acute and long-term study. Materials and methods. Sprague-Dawley rats were used in a model of TM perforation. The perforation was performed with a laser system. Stem cells were applied and the healing time and morphological analysis were performed with light and transmission electron microscope. Stiffness was examined by moiré interferometry. Results. The stiffness of the perforated and healed TM was restored after just 2 weeks. In the chronic perforation model, mesenchymal stem cells enhanced the healing.</description><identifier>ISSN: 0001-6489</identifier><identifier>ISSN: 1651-2251</identifier><identifier>EISSN: 1651-2251</identifier><identifier>DOI: 10.1080/00016480701762508</identifier><identifier>PMID: 18368564</identifier><identifier>CODEN: AOLAAJ</identifier><language>eng</language><publisher>Stockholm: Informa UK Ltd</publisher><subject>Animals ; Biological and medical sciences ; Chronic Disease ; Disease Models, Animal ; Follow-Up Studies ; healing ; Interferometry - methods ; laser myringotomy ; Medical sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Microscopy, Electron, Transmission ; moiré interferometry ; Myringoplasty - methods ; Otorhinolaryngology. Stomatology ; Rats ; Rats, Sprague-Dawley ; Sound ; stem cell ; Stem Cell Transplantation - methods ; Treatment Outcome ; Tympanic membrane ; Tympanic Membrane - injuries ; Tympanic Membrane - ultrastructure ; Tympanic Membrane Perforation - pathology ; Tympanic Membrane Perforation - physiopathology ; Tympanic Membrane Perforation - surgery ; Wound Healing - physiology</subject><ispartof>Acta oto-laryngologica, 2008-01, Vol.128 (4), p.352-359</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-bd1bb2aeaf1560a8e8473908bbaeda19683e7904c05c3dec830629956057e0c53</citedby><cites>FETCH-LOGICAL-c560t-bd1bb2aeaf1560a8e8473908bbaeda19683e7904c05c3dec830629956057e0c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00016480701762508$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00016480701762508$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>230,315,781,785,886,27928,27929,59651,59757,60440,60546,61225,61260,61406,61441</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20242324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18368564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-101022$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:116780733$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahman, Anisur</creatorcontrib><creatorcontrib>Olivius, Petri</creatorcontrib><creatorcontrib>Dirckx, Joris</creatorcontrib><creatorcontrib>Von Unge, Magnus</creatorcontrib><creatorcontrib>Hultcrantz, Malou</creatorcontrib><title>Stem cells and enhanced healing of chronic tympanic membrane perforation</title><title>Acta oto-laryngologica</title><addtitle>Acta Otolaryngol</addtitle><description>Conclusions. Important information about the basic reparative process of tympanic membrane (TM) healing is shown, which can be incorporated for further clinical understanding. This provides a basis for the exploration of stem cell treatment for TM perforations and holds promise for future improvements. Objectives. This study aimed to analyse the healing of TM perforation by using stem cells and the stiffness of the membrane was tested in an acute and long-term study. Materials and methods. Sprague-Dawley rats were used in a model of TM perforation. The perforation was performed with a laser system. Stem cells were applied and the healing time and morphological analysis were performed with light and transmission electron microscope. Stiffness was examined by moiré interferometry. Results. The stiffness of the perforated and healed TM was restored after just 2 weeks. In the chronic perforation model, mesenchymal stem cells enhanced the healing.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Disease Models, Animal</subject><subject>Follow-Up Studies</subject><subject>healing</subject><subject>Interferometry - methods</subject><subject>laser myringotomy</subject><subject>Medical sciences</subject><subject>MEDICIN</subject><subject>Medicin och hälsovetenskap</subject><subject>MEDICINE</subject><subject>Microscopy, Electron, Transmission</subject><subject>moiré interferometry</subject><subject>Myringoplasty - methods</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sound</subject><subject>stem cell</subject><subject>Stem Cell Transplantation - methods</subject><subject>Treatment Outcome</subject><subject>Tympanic membrane</subject><subject>Tympanic Membrane - injuries</subject><subject>Tympanic Membrane - ultrastructure</subject><subject>Tympanic Membrane Perforation - pathology</subject><subject>Tympanic Membrane Perforation - physiopathology</subject><subject>Tympanic Membrane Perforation - surgery</subject><subject>Wound Healing - physiology</subject><issn>0001-6489</issn><issn>1651-2251</issn><issn>1651-2251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks1u1DAUhS0EokPhAdigbOgu9NqOE1uwqcpPK1XqosDWcpybjksSBztRNW-Po0lbIcSsfG1_59i-x4S8pfCBgoRTAKBlIaECWpVMgHxGNrQUNGdM0Odks-znCVBH5FWMd8tUSfGSHFHJSynKYkMubibsM4tdFzMzNBkOWzNYbLItms4Nt5lvM7sNfnA2m3b9aJaix74OZsBsxND6YCbnh9fkRWu6iG_W8Zj8-Prl-_lFfnX97fL87Cq3ooQprxta18ygaWmaG4myqLgCWdcGG0NVKTlWCgoLwvIGreRQMqUSKyoEK_gxyfe-8R7HudZjcL0JO-2N0-vSr1ShFqkRqkq8-i8_Bt88iR6ElJZV6innB8_67H6eaR9udedmTYECY4k_2fPJ-PeMcdK9i0tvU6_8HHUFBZeqggTSPWiDjzFg-2hNQS_R6n-iTZp3q_lc99g8KdYsE_B-BUy0pmtTQtbFR44BKxhnC_dpz7khhdebex-6Rk9m1_nwIOKH7vHxL_nyUaatNQH1nZ_DkMI_8Io_Fx3RhA</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Rahman, Anisur</creator><creator>Olivius, Petri</creator><creator>Dirckx, Joris</creator><creator>Von Unge, Magnus</creator><creator>Hultcrantz, Malou</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DG8</scope></search><sort><creationdate>20080101</creationdate><title>Stem cells and enhanced healing of chronic tympanic membrane perforation</title><author>Rahman, Anisur ; Olivius, Petri ; Dirckx, Joris ; Von Unge, Magnus ; Hultcrantz, Malou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-bd1bb2aeaf1560a8e8473908bbaeda19683e7904c05c3dec830629956057e0c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Disease Models, Animal</topic><topic>Follow-Up Studies</topic><topic>healing</topic><topic>Interferometry - methods</topic><topic>laser myringotomy</topic><topic>Medical sciences</topic><topic>MEDICIN</topic><topic>Medicin och hälsovetenskap</topic><topic>MEDICINE</topic><topic>Microscopy, Electron, Transmission</topic><topic>moiré interferometry</topic><topic>Myringoplasty - methods</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sound</topic><topic>stem cell</topic><topic>Stem Cell Transplantation - methods</topic><topic>Treatment Outcome</topic><topic>Tympanic membrane</topic><topic>Tympanic Membrane - injuries</topic><topic>Tympanic Membrane - ultrastructure</topic><topic>Tympanic Membrane Perforation - pathology</topic><topic>Tympanic Membrane Perforation - physiopathology</topic><topic>Tympanic Membrane Perforation - surgery</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahman, Anisur</creatorcontrib><creatorcontrib>Olivius, Petri</creatorcontrib><creatorcontrib>Dirckx, Joris</creatorcontrib><creatorcontrib>Von Unge, Magnus</creatorcontrib><creatorcontrib>Hultcrantz, Malou</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Linköpings universitet</collection><jtitle>Acta oto-laryngologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahman, Anisur</au><au>Olivius, Petri</au><au>Dirckx, Joris</au><au>Von Unge, Magnus</au><au>Hultcrantz, Malou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stem cells and enhanced healing of chronic tympanic membrane perforation</atitle><jtitle>Acta oto-laryngologica</jtitle><addtitle>Acta Otolaryngol</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>128</volume><issue>4</issue><spage>352</spage><epage>359</epage><pages>352-359</pages><issn>0001-6489</issn><issn>1651-2251</issn><eissn>1651-2251</eissn><coden>AOLAAJ</coden><abstract>Conclusions. Important information about the basic reparative process of tympanic membrane (TM) healing is shown, which can be incorporated for further clinical understanding. This provides a basis for the exploration of stem cell treatment for TM perforations and holds promise for future improvements. Objectives. This study aimed to analyse the healing of TM perforation by using stem cells and the stiffness of the membrane was tested in an acute and long-term study. Materials and methods. Sprague-Dawley rats were used in a model of TM perforation. The perforation was performed with a laser system. Stem cells were applied and the healing time and morphological analysis were performed with light and transmission electron microscope. Stiffness was examined by moiré interferometry. Results. The stiffness of the perforated and healed TM was restored after just 2 weeks. In the chronic perforation model, mesenchymal stem cells enhanced the healing.</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>18368564</pmid><doi>10.1080/00016480701762508</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Animals Biological and medical sciences Chronic Disease Disease Models, Animal Follow-Up Studies healing Interferometry - methods laser myringotomy Medical sciences MEDICIN Medicin och hälsovetenskap MEDICINE Microscopy, Electron, Transmission moiré interferometry Myringoplasty - methods Otorhinolaryngology. Stomatology Rats Rats, Sprague-Dawley Sound stem cell Stem Cell Transplantation - methods Treatment Outcome Tympanic membrane Tympanic Membrane - injuries Tympanic Membrane - ultrastructure Tympanic Membrane Perforation - pathology Tympanic Membrane Perforation - physiopathology Tympanic Membrane Perforation - surgery Wound Healing - physiology |
| title | Stem cells and enhanced healing of chronic tympanic membrane perforation |
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