In Vitro and In Vivo Evaluation of Carboplatin Delivery to the Eye Using Hydrogel-Iontophoresis

Purpose: To investigate in vitro and in vivo hydrogel-iontophoresis delivery of carboplatin to the eye. Methods: Iontophoresis was applied on agar gels resembling the eye using different current intensities and durations. Transscleral iontophoresis was performed on healthy rabbits, applying 0, 1, an...

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Veröffentlicht in:	Current eye research 2008, Vol.33 (3), p.269-275
Hauptverfasser:	Eljarrat-Binstock, Esther, Domb, Abraham J., Orucov, Faik, Dagan, Amir, Frucht-Pery, Joseph, Pe'er, Jacob
Format:	Artikel
Sprache:	eng
Schlagworte:	Agar - metabolism Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics carboplatin Carboplatin - administration & dosage Carboplatin - pharmacokinetics Drug Delivery Systems eye hydrogel iontophoresis Iontophoresis - methods Male Methacrylates - administration & dosage Rabbits retinoblastoma Sclera - metabolism
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