Isolation and Identification of Rhizoxin Analogs from Pseudomonas fluorescens Pf-5 by Using a Genomic Mining Strategy

The products synthesized from a hybrid polyketide synthase/nonribosomal peptide synthetase gene cluster in the genome of Pseudomonas fluorescens Pf-5 were identified using a genomics-guided strategy involving insertional mutagenesis and subsequent metabolite profiling. Five analogs of rhizoxin, a 16...

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Veröffentlicht in:	Applied and Environmental Microbiology 2008-05, Vol.74 (10), p.3085-3093
Hauptverfasser:	Loper, Joyce E, Henkels, Marcella D, Shaffer, Brenda T, Valeriote, Frederick A, Gross, Harald
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Antifungal Agents - toxicity antifungal properties Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Antitumor activity Bacteria bioassays Biological and medical sciences biosynthesis Botrytis - drug effects Botrytis cinerea Cell Line, Tumor cell lines chemical structure Cucumis - drug effects Cucumis sativus cytotoxicity Evolutionary and Genomic Microbiology Flowers & plants Fundamental and applied biological sciences. Psychology Gene expression genes genetic techniques and protocols genome genomic mining Genomics human cell lines Humans Inhibitory Concentration 50 macrolides Macrolides - chemistry Macrolides - isolation & purification Macrolides - pharmacology Macrolides - toxicity Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Microbiology Molecular Structure Multigene Family Mutagenesis, Insertional Mutation neoplasms Oryza - drug effects Oryza sativa peptide synthase Peptide Synthases - genetics Peptides Phytophthora - drug effects Phytophthora ramorum phytotoxicity Pisum sativum Pisum sativum - drug effects plant pathogenic fungi Plant Roots - drug effects polyketide synthase Polyketide Synthases - genetics Pseudomonas fluorescens Pseudomonas fluorescens - chemistry Pseudomonas fluorescens - enzymology Pseudomonas fluorescens - genetics rhizosphere rhizoxin analogs soil bacteria Toxicity
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