Increased mitochondrial oxidative damage and oxidative DNA damage contributes to the neurodegenerative process in sporadic amyotrophic lateral sclerosis
To investigate the possibility that mitochondrial oxidative damage or oxidative DNA damage or both contribute to the neurodegenerative process of sporadic amyotrophic lateral sclerosis (sALS), this study used high-performance liquid chromatography with an electrochemical detector to measure the conc...
Gespeichert in:
| Veröffentlicht in: | Free radical research 2008-03, Vol.42 (3), p.221-225 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 225 |
|---|---|
| container_issue | 3 |
| container_start_page | 221 |
| container_title | Free radical research |
| container_volume | 42 |
| creator | Murata, Takahiko Ohtsuka, Chigumi Terayama, Yasuo |
| description | To investigate the possibility that mitochondrial oxidative damage or oxidative DNA damage or both contribute to the neurodegenerative process of sporadic amyotrophic lateral sclerosis (sALS), this study used high-performance liquid chromatography with an electrochemical detector to measure the concentrations of the reduced and oxidized forms of coenzyme Q10 (CoQ10) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the cerebrospinal fluid (CSF) of 17 patients with sALS and 17 age-matched controls with no neurological diseases. The percentage of oxidized CoQ10 in the CSF of sALS patients was greater than that in the CSF of controls (p |
| doi_str_mv | 10.1080/10715760701877262 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_18344116</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70403435</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-9da37cc66fb678f73e17375741bda2a67cdd932511c953e0e25d7c25847b5eac3</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS1ERUvhAdggr9gF_JPEuYJNVf4qVWUDa2tiTxpXjn2xHeC-CY-Lq3sRVJW6mtH4O0fHM4S84Ow1ZwN7w5nineqZYnxQSvTiETnhTGwa0Sr2-LZXvKmAOCZPc75hjMu2U0_IMR9k23Len5DfF8EkhIyWLq5EM8dgkwNP4y9nobgfSC0scI0Ugv1v-P7q7O-DiaEkN64FMy2RlhlpwDVFi9cYMO35bYoGc6Yu0LyNCawzFJZdLClu59p7KBX1NBuPKWaXn5GjCXzG54d6Sr59_PD1_HNz-eXTxfnZZWPqH0uzsSCVMX0_jb0aJiWRK6k61fLRgoBeGWs3UnScm00nkaHorDKiG1o1dghGnpJXe9-a8PuKuejFZYPeQ8C4Zq1Yy2QruwryPWhqvpxw0tvkFkg7zZm-PYe-d46qeXkwX8cF7T_FYf8VeLcHXJhiWuBnTN7qAjsf05QgGJe1fMj_7R35jODLbCChvolrCnVxD6T7A38prrQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70403435</pqid></control><display><type>article</type><title>Increased mitochondrial oxidative damage and oxidative DNA damage contributes to the neurodegenerative process in sporadic amyotrophic lateral sclerosis</title><source>MEDLINE</source><source>Taylor & Francis Journals Complete</source><creator>Murata, Takahiko ; Ohtsuka, Chigumi ; Terayama, Yasuo</creator><creatorcontrib>Murata, Takahiko ; Ohtsuka, Chigumi ; Terayama, Yasuo</creatorcontrib><description>To investigate the possibility that mitochondrial oxidative damage or oxidative DNA damage or both contribute to the neurodegenerative process of sporadic amyotrophic lateral sclerosis (sALS), this study used high-performance liquid chromatography with an electrochemical detector to measure the concentrations of the reduced and oxidized forms of coenzyme Q10 (CoQ10) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the cerebrospinal fluid (CSF) of 17 patients with sALS and 17 age-matched controls with no neurological diseases. The percentage of oxidized CoQ10 in the CSF of sALS patients was greater than that in the CSF of controls (p<0.002) and was negatively correlated with the duration of illness ( =−0.61, p<0.01). The concentration of 8-OHdG in the CSF of sALS patients was greater than that in the CSF of controls (p<0.005) and was positively correlated with the duration of illness ( =0.53, p<0.005). The percentage of oxidized CoQ10 was correlated with the concentrations of 8-OHdG in the CSF of sALS patients ( =−0.53, p<0.05). These results suggest that both mitochondrial oxidative damage and oxidative DNA damage play important roles in the pathogenesis of sporadic amyotrophic lateral sclerosis.</description><identifier>ISSN: 1071-5762</identifier><identifier>EISSN: 1029-2470</identifier><identifier>DOI: 10.1080/10715760701877262</identifier><identifier>PMID: 18344116</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>8-hydroxy-2′-deoxyguanosine ; Aged ; Amyotrophic Lateral Sclerosis - cerebrospinal fluid ; Amyotrophic Lateral Sclerosis - metabolism ; Apoptosis ; Case-Control Studies ; cerebrospinal fluid ; Chromatography - methods ; coenzyme Q10 ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - chemistry ; DNA Damage ; Humans ; Middle Aged ; Mitochondria - metabolism ; Neurodegenerative Diseases - cerebrospinal fluid ; Neurodegenerative Diseases - metabolism ; Oxidation-Reduction ; Oxidative Stress ; Oxygen - chemistry ; Oxygen - metabolism ; Sporadic amyotrophic lateral sclerosis ; Time Factors</subject><ispartof>Free radical research, 2008-03, Vol.42 (3), p.221-225</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-9da37cc66fb678f73e17375741bda2a67cdd932511c953e0e25d7c25847b5eac3</citedby><cites>FETCH-LOGICAL-c470t-9da37cc66fb678f73e17375741bda2a67cdd932511c953e0e25d7c25847b5eac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10715760701877262$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10715760701877262$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18344116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murata, Takahiko</creatorcontrib><creatorcontrib>Ohtsuka, Chigumi</creatorcontrib><creatorcontrib>Terayama, Yasuo</creatorcontrib><title>Increased mitochondrial oxidative damage and oxidative DNA damage contributes to the neurodegenerative process in sporadic amyotrophic lateral sclerosis</title><title>Free radical research</title><addtitle>Free Radic Res</addtitle><description>To investigate the possibility that mitochondrial oxidative damage or oxidative DNA damage or both contribute to the neurodegenerative process of sporadic amyotrophic lateral sclerosis (sALS), this study used high-performance liquid chromatography with an electrochemical detector to measure the concentrations of the reduced and oxidized forms of coenzyme Q10 (CoQ10) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the cerebrospinal fluid (CSF) of 17 patients with sALS and 17 age-matched controls with no neurological diseases. The percentage of oxidized CoQ10 in the CSF of sALS patients was greater than that in the CSF of controls (p<0.002) and was negatively correlated with the duration of illness ( =−0.61, p<0.01). The concentration of 8-OHdG in the CSF of sALS patients was greater than that in the CSF of controls (p<0.005) and was positively correlated with the duration of illness ( =0.53, p<0.005). The percentage of oxidized CoQ10 was correlated with the concentrations of 8-OHdG in the CSF of sALS patients ( =−0.53, p<0.05). These results suggest that both mitochondrial oxidative damage and oxidative DNA damage play important roles in the pathogenesis of sporadic amyotrophic lateral sclerosis.</description><subject>8-hydroxy-2′-deoxyguanosine</subject><subject>Aged</subject><subject>Amyotrophic Lateral Sclerosis - cerebrospinal fluid</subject><subject>Amyotrophic Lateral Sclerosis - metabolism</subject><subject>Apoptosis</subject><subject>Case-Control Studies</subject><subject>cerebrospinal fluid</subject><subject>Chromatography - methods</subject><subject>coenzyme Q10</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - chemistry</subject><subject>DNA Damage</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Mitochondria - metabolism</subject><subject>Neurodegenerative Diseases - cerebrospinal fluid</subject><subject>Neurodegenerative Diseases - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Oxygen - chemistry</subject><subject>Oxygen - metabolism</subject><subject>Sporadic amyotrophic lateral sclerosis</subject><subject>Time Factors</subject><issn>1071-5762</issn><issn>1029-2470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS1ERUvhAdggr9gF_JPEuYJNVf4qVWUDa2tiTxpXjn2xHeC-CY-Lq3sRVJW6mtH4O0fHM4S84Ow1ZwN7w5nineqZYnxQSvTiETnhTGwa0Sr2-LZXvKmAOCZPc75hjMu2U0_IMR9k23Len5DfF8EkhIyWLq5EM8dgkwNP4y9nobgfSC0scI0Ugv1v-P7q7O-DiaEkN64FMy2RlhlpwDVFi9cYMO35bYoGc6Yu0LyNCawzFJZdLClu59p7KBX1NBuPKWaXn5GjCXzG54d6Sr59_PD1_HNz-eXTxfnZZWPqH0uzsSCVMX0_jb0aJiWRK6k61fLRgoBeGWs3UnScm00nkaHorDKiG1o1dghGnpJXe9-a8PuKuejFZYPeQ8C4Zq1Yy2QruwryPWhqvpxw0tvkFkg7zZm-PYe-d46qeXkwX8cF7T_FYf8VeLcHXJhiWuBnTN7qAjsf05QgGJe1fMj_7R35jODLbCChvolrCnVxD6T7A38prrQ</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Murata, Takahiko</creator><creator>Ohtsuka, Chigumi</creator><creator>Terayama, Yasuo</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Increased mitochondrial oxidative damage and oxidative DNA damage contributes to the neurodegenerative process in sporadic amyotrophic lateral sclerosis</title><author>Murata, Takahiko ; Ohtsuka, Chigumi ; Terayama, Yasuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-9da37cc66fb678f73e17375741bda2a67cdd932511c953e0e25d7c25847b5eac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>8-hydroxy-2′-deoxyguanosine</topic><topic>Aged</topic><topic>Amyotrophic Lateral Sclerosis - cerebrospinal fluid</topic><topic>Amyotrophic Lateral Sclerosis - metabolism</topic><topic>Apoptosis</topic><topic>Case-Control Studies</topic><topic>cerebrospinal fluid</topic><topic>Chromatography - methods</topic><topic>coenzyme Q10</topic><topic>Deoxyguanosine - analogs & derivatives</topic><topic>Deoxyguanosine - chemistry</topic><topic>DNA Damage</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Mitochondria - metabolism</topic><topic>Neurodegenerative Diseases - cerebrospinal fluid</topic><topic>Neurodegenerative Diseases - metabolism</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress</topic><topic>Oxygen - chemistry</topic><topic>Oxygen - metabolism</topic><topic>Sporadic amyotrophic lateral sclerosis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murata, Takahiko</creatorcontrib><creatorcontrib>Ohtsuka, Chigumi</creatorcontrib><creatorcontrib>Terayama, Yasuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Free radical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murata, Takahiko</au><au>Ohtsuka, Chigumi</au><au>Terayama, Yasuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased mitochondrial oxidative damage and oxidative DNA damage contributes to the neurodegenerative process in sporadic amyotrophic lateral sclerosis</atitle><jtitle>Free radical research</jtitle><addtitle>Free Radic Res</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>42</volume><issue>3</issue><spage>221</spage><epage>225</epage><pages>221-225</pages><issn>1071-5762</issn><eissn>1029-2470</eissn><abstract>To investigate the possibility that mitochondrial oxidative damage or oxidative DNA damage or both contribute to the neurodegenerative process of sporadic amyotrophic lateral sclerosis (sALS), this study used high-performance liquid chromatography with an electrochemical detector to measure the concentrations of the reduced and oxidized forms of coenzyme Q10 (CoQ10) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the cerebrospinal fluid (CSF) of 17 patients with sALS and 17 age-matched controls with no neurological diseases. The percentage of oxidized CoQ10 in the CSF of sALS patients was greater than that in the CSF of controls (p<0.002) and was negatively correlated with the duration of illness ( =−0.61, p<0.01). The concentration of 8-OHdG in the CSF of sALS patients was greater than that in the CSF of controls (p<0.005) and was positively correlated with the duration of illness ( =0.53, p<0.005). The percentage of oxidized CoQ10 was correlated with the concentrations of 8-OHdG in the CSF of sALS patients ( =−0.53, p<0.05). These results suggest that both mitochondrial oxidative damage and oxidative DNA damage play important roles in the pathogenesis of sporadic amyotrophic lateral sclerosis.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>18344116</pmid><doi>10.1080/10715760701877262</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1071-5762 |
| ispartof | Free radical research, 2008-03, Vol.42 (3), p.221-225 |
| issn | 1071-5762 1029-2470 |
| language | eng |
| recordid | cdi_pubmed_primary_18344116 |
| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | 8-hydroxy-2′-deoxyguanosine Aged Amyotrophic Lateral Sclerosis - cerebrospinal fluid Amyotrophic Lateral Sclerosis - metabolism Apoptosis Case-Control Studies cerebrospinal fluid Chromatography - methods coenzyme Q10 Deoxyguanosine - analogs & derivatives Deoxyguanosine - chemistry DNA Damage Humans Middle Aged Mitochondria - metabolism Neurodegenerative Diseases - cerebrospinal fluid Neurodegenerative Diseases - metabolism Oxidation-Reduction Oxidative Stress Oxygen - chemistry Oxygen - metabolism Sporadic amyotrophic lateral sclerosis Time Factors |
| title | Increased mitochondrial oxidative damage and oxidative DNA damage contributes to the neurodegenerative process in sporadic amyotrophic lateral sclerosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T04%3A14%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20mitochondrial%20oxidative%20damage%20and%20oxidative%20DNA%20damage%20contributes%20to%20the%20neurodegenerative%20process%20in%20sporadic%20amyotrophic%20lateral%20sclerosis&rft.jtitle=Free%20radical%20research&rft.au=Murata,%20Takahiko&rft.date=2008-03-01&rft.volume=42&rft.issue=3&rft.spage=221&rft.epage=225&rft.pages=221-225&rft.issn=1071-5762&rft.eissn=1029-2470&rft_id=info:doi/10.1080/10715760701877262&rft_dat=%3Cproquest_pubme%3E70403435%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70403435&rft_id=info:pmid/18344116&rfr_iscdi=true |