Contribution of P2Y(1) receptors to ADP signalling in mouse spinal cord cultures

Mixed neuronal and glial cell spinal cord cultures from neonates express ADP sensitive P2Y(1,12&13) receptors. ADP (10microM) evoked increases in intracellular calcium that were essentially abolished by the P2Y(1) receptor antagonist MRS2179 (10microM), responses were also absent in preparations...

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Veröffentlicht in:	Neuroscience letters 2008-04, Vol.435 (3), p.190
Hauptverfasser:	Atterbury-Thomas, Amelia E, Leon, Catherine, Gachet, Christian, Forsythe, Ian D, Evans, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - analogs & derivatives Adenosine Diphosphate - metabolism Adenosine Diphosphate - pharmacology Aniline Compounds - metabolism Animals Calcium - metabolism Dose-Response Relationship, Drug Drug Interactions Female Male Mice Mice, Inbred C57BL Mice, Knockout Purinergic P2 Receptor Antagonists Receptors, Purinergic P2 - deficiency Receptors, Purinergic P2 - physiology Receptors, Purinergic P2Y1 Signal Transduction - drug effects Signal Transduction - physiology Spinal Cord - drug effects Spinal Cord - physiology Time Factors Tissue Culture Techniques Uridine Triphosphate - pharmacology Xanthenes - metabolism
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