X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations

X chromosome inactivation (XCI) is an essential mechanism for dosage compensation of X-linked genes in female cells. We report that subcultures from lines of female human embryonic stem cells (hESCs) exhibit variation (0-100%) for XCI markers, including XIST RNA expression and enrichment of histone...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-03, Vol.105 (12), p.4709-4714
Hauptverfasser:	Shen, Yin, Matsuno, Youko, Fouse, Shaun D, Rao, Nagesh, Root, Sierra, Xu, Renhe, Pellegrini, Matteo, Riggs, Arthur D, Fan, Guoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cells, Cultured Chromosomes CpG Islands - genetics DNA Methylation DNA, Complementary - genetics Dosage Compensation, Genetic Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Embryos Epigenesis, Genetic Female Females Gene expression Genes Genes, X-Linked Genetic Markers Genetics Genotype Humans Methylation Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic - genetics Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA, Long Noncoding RNA, Untranslated - genetics RNA, Untranslated - metabolism Sex chromosomes Somatic cells Stem cells Subcultures X Chromosome inactivation X Chromosome Inactivation - genetics X linked genes
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