Antidepressant response and intolerance to SSRI is not influenced by G-protein beta3 subunit gene C825T polymorphism in Japanese major depressive patients

The G-protein beta3 subunit (GNB3) gene is a key modulator of signal transduction and is a major candidate for SSRIs response. The aim of the present study is to test a possible effect of the C825T polymorphism on the antidepressant response and intolerance to selective serotonin reuptake inhibitors...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2008-05, Vol.32 (4), p.1041
Hauptverfasser:	Kato, Masaki, Wakeno, Masataka, Okugawa, Gaku, Fukuda, Tsuyoshi, Takekita, Yoshiteru, Hosoi, Yuka, Azuma, Junichi, Kinoshita, Toshihiko, Serretti, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antidepressive Agents - adverse effects Antidepressive Agents - blood Antidepressive Agents - therapeutic use Depressive Disorder, Major - drug therapy Depressive Disorder, Major - genetics Depressive Disorder, Major - psychology Female Fluvoxamine - adverse effects Fluvoxamine - blood Fluvoxamine - therapeutic use Genotype Heterotrimeric GTP-Binding Proteins - genetics Humans Japan Male Middle Aged Paroxetine - adverse effects Paroxetine - blood Paroxetine - therapeutic use Polymorphism, Genetic - genetics Psychiatric Status Rating Scales Serotonin Uptake Inhibitors - adverse effects Serotonin Uptake Inhibitors - blood Serotonin Uptake Inhibitors - therapeutic use
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