Functional characterization of residues within the carnitine/acylcarnitine translocase RX2PANAAXF distinct motif

The mitochondrial carnitine/acylcarnitine carrier (CAC) is characterized by the presence of a distinct motif, RXXPANAAXF, within its sixth transmembrane -helix. In this study, we analysed the role of the amino acids of this motif in the structure-function relationships of the human CAC by using two...

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Veröffentlicht in:	Molecular membrane biology 2008-02, Vol.25 (2), p.152-163
Hauptverfasser:	Ramon De Lucas, J., Indiveri, Cesare, Tonazzi, Annamaria, Perez, Patricia, Giangregorio, Nicola, Iacobazzi, Vito, Palmieri, Ferdinando
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Amino Acids - metabolism Aspergillus nidulans Aspergillus nidulans - enzymology Aspergillus nidulans - growth & development Biological Transport Calorimetry Carnitine - metabolism Carnitine Acyltransferases - chemistry Carnitine Acyltransferases - metabolism carnitine/acylcarnitine translocase Humans Kinetics liposomes Liposomes - metabolism mitochondrial carriers Models, Molecular Molecular Sequence Data Mutant Proteins - chemistry Mutant Proteins - metabolism Protein Structure, Secondary Recombinant Proteins - metabolism site-directed mutagenesis Structure-Activity Relationship Time Factors Transformation, Genetic Tritium - metabolism
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