MG132 proteasome inhibitor modulates proinflammatory cytokines production and expression of their receptors in U937 cells: involvement of nuclear factor-kappaB and activator protein-1

In response to inflammatory stimuli, monocytes/macrophages secrete greater quantities of the proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6. The inflammatory process and the innate immune response are related to the activation of several tra...

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Veröffentlicht in:	Immunology 2008-08, Vol.124 (4), p.534
Hauptverfasser:	Ortiz-Lazareno, Pablo C, Hernandez-Flores, Georgina, Dominguez-Rodriguez, Jorge R, Lerma-Diaz, Jose M, Jave-Suarez, Luis F, Aguilar-Lemarroy, Adriana, Gomez-Contreras, Piedad C, Scott-Algara, Daniel, Bravo-Cuellar, Alejandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Cysteine Proteinase Inhibitors - pharmacology Cytokines - biosynthesis Humans I-kappa B Proteins - metabolism Inflammation Mediators - metabolism Interleukin-1beta - biosynthesis Interleukin-6 - biosynthesis Leupeptins - pharmacology Lipopolysaccharides - immunology NF-kappa B - metabolism Receptors, Cytokine - metabolism Receptors, Interleukin-1 Type I - metabolism Receptors, Interleukin-6 - metabolism Receptors, Tumor Necrosis Factor, Type I - metabolism Tetradecanoylphorbol Acetate - immunology Transcription Factor AP-1 - metabolism Tumor Necrosis Factor-alpha - biosynthesis U937 Cells
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