Neuro-inflammatory response in rats chronically exposed to (137)Cesium

After the Chernobyl nuclear accident, behavioural disorders and central nervous system diseases were frequently observed in populations living in the areas contaminated by (137)Cs. Until now, these neurological disturbances were not elucidated, but the presence of a neuro-inflammatory response could...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2008-03, Vol.29 (2), p.343
Hauptverfasser:	Lestaevel, Philippe, Grandcolas, Line, Paquet, François, Voisin, Philippe, Aigueperse, Jocelyne, Gourmelon, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cesium Radioisotopes - toxicity Chernobyl Nuclear Accident Cytokines - genetics Cytokines - metabolism Enzyme Induction Enzyme-Linked Immunosorbent Assay Frontal Lobe - enzymology Frontal Lobe - metabolism Frontal Lobe - radiation effects Gene Expression - radiation effects Hippocampus - enzymology Hippocampus - metabolism Hippocampus - radiation effects Interleukin-10 - metabolism Interleukin-1beta - metabolism Interleukin-6 - metabolism Interleukin-8 - metabolism Male Neuritis - etiology Neuritis - genetics Neuritis - metabolism Nitric Oxide Synthase Type II - biosynthesis Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type III Polymerase Chain Reaction Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Transforming Growth Factor beta - metabolism Tumor Necrosis Factor-alpha - metabolism Up-Regulation
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