Green tea catechins prevent cognitive deficits caused by Abeta1-40 in rats

Amyloid beta peptide (Abeta)-induced oxidative stress is involved in the pathogenesis of Alzheimer's disease (AD). In contrast, green tea catechins confer potent antioxidative defense to brain neurons. Therefore, we examined whether long-term administration of green tea catechins [Polyphenon E...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2008-09, Vol.19 (9), p.619
Hauptverfasser:	Haque, Abdul M, Hashimoto, Michio, Katakura, Masanori, Hara, Yukihiko, Shido, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - toxicity Animals Behavior, Animal - drug effects Catechin - analogs & derivatives Catechin - pharmacology Cholesterol - blood Ferric Compounds - blood Male Maze Learning - drug effects Oxidation-Reduction Peptide Fragments - antagonists & inhibitors Peptide Fragments - toxicity Rats Rats, Wistar Reactive Oxygen Species - metabolism Tea Thiobarbituric Acid Reactive Substances - metabolism Triglycerides - blood
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