All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB

Retinoids are signaling molecules that are involved in proliferation, differentiation, and apoptosis during development. Retinoids exert their effects, in part, by binding to nuclear receptors, thereby altering gene expression. Clinical use of retinoids in the treatment of neuroblastoma is of intere...

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Veröffentlicht in:	Free radical biology & medicine 2008-04, Vol.44 (8), p.1610
Hauptverfasser:	Kiningham, Kinsley K, Cardozo, Zina-Ann, Cook, Carla, Cole, Marsha P, Stewart, John C, Tassone, Mariela, Coleman, Mitchell C, Spitz, Douglas R
Format:	Artikel
Sprache:	eng
Schlagworte:	Enzyme Induction Gene Expression Regulation, Enzymologic - drug effects Humans I-kappa B Proteins - metabolism Neuroblastoma - enzymology Neuroblastoma - metabolism NF-kappa B - metabolism RNA, Messenger - drug effects Superoxide Dismutase - biosynthesis Tretinoin - pharmacology Tumor Cells, Cultured Up-Regulation
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