Spin-labeled rifamycin: biological activity

3-[(2,2,6,6-Tetramethylpiperidine-4-ylimino)methyl]rifamycin (4) and spin-labeled rifamycin-3-[(2,2,6,6-tetramethyl-1-oxyl-piperidine-4-ylimino)methyl]rifamycin (1) were prepared. The structures of these compounds were determined by IR, UV, MS and 1H NMR of 4. The ESR-spectrum of 1 is a symmetric tr...

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Veröffentlicht in:	Pharmazie 2008-01, Vol.63 (1), p.61-66
Hauptverfasser:	Raykov, Z. Z., Vassilev, K., Grigorova, G., Lyapova, A., Alexiev, A., Petrov, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Bacteria - drug effects Cell Line, Tumor Cell Survival - drug effects Female Gamma Rays Humans Indicators and Reagents Magnetic Resonance Spectroscopy Male Mice Microbial Sensitivity Tests Oxidative Stress - drug effects Oxidative Stress - radiation effects Rifamycins - chemical synthesis Rifamycins - pharmacology Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Spin Labels - chemical synthesis Tetrazolium Salts Thiazoles
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