Phase 3, randomized, double-blind study of plasma-derived human thrombin versus bovine thrombin in achieving hemostasis in patients undergoing surgery

ABSTRACT Objective: To compare the effectiveness of plasma-derived human thrombin and bovine thrombin for achieving hemostasis during surgery. Methods: Adults (N = 305) with ≥ 1 mild or moderate bleeding site not manageable by conventional modalities during elective cardiovascular, neurologic, or ge...

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Veröffentlicht in:	Current medical research and opinion 2008-03, Vol.24 (3), p.785-794
Hauptverfasser:	Doria, Cataldo, Fischer, Craig P., Wood, Christopher G., Mark Li, P., Marra, Steven, Hart, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Loss, Surgical - prevention & control Cardiovascular surgical procedures Cardiovascular Surgical Procedures - methods Cattle Double-Blind Method Female General surgery Hemostasis Hemostasis, Surgical Hemostatics - blood Human thrombin Humans Immunogenicity Intraoperative Complications - prevention & control Length of Stay Male Middle Aged Neurosurgical Procedures Perioperative Care Postoperative Hemorrhage - prevention & control Prospective Studies Seroconversion Thrombin - therapeutic use Thrombin Time
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