Retinoic acid enhances prostaglandin E2 production through increased expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in rat brain microglia

Retinoic acid (RA) is a well‐known antiinflammatory agent. In this study, we show that RA has a dual effect on cyclooxygenase‐2 (COX‐2) expression in inflammatory activated microglia, the resident brain macrophages. After treatment of microglia with LPS or thrombin, COX‐2 expression was induced in t...

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Veröffentlicht in:	Journal of neuroscience research 2008-05, Vol.86 (6), p.1353-1360
Hauptverfasser:	Kim, Beomsue, Lee, Jee-Hyung, Yang, Myung-Soon, Jou, Ilo, Joe, Eun-Hye
Format:	Artikel
Sprache:	eng
Schlagworte:	15d-PGJ2 all-trans retinoic acid Animals Anti-Inflammatory Agents - pharmacology Blotting, Western Brain - drug effects Brain - metabolism Cells, Cultured COX-2 Cyclooxygenase 2 - biosynthesis Cyclooxygenase 2 - drug effects Dinoprostone - biosynthesis Enzyme-Linked Immunosorbent Assay Inflammation - chemically induced Intramolecular Oxidoreductases - biosynthesis Lipopolysaccharides - toxicity microglia Microglia - drug effects Microglia - metabolism Microsomes - metabolism mPGES-1 PGE2 Prostaglandin-E Synthases Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Thrombin - toxicity Tretinoin - pharmacology
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