Expression of c-erbB-2 and c-met proteins in gastric adenoma and adenocarcinoma
The aim of this study was to investigate the immunohistochemical overexpression of c-erbB-2 and c-met proteins according to the histopathological parameters such as grade of dysplasia, histological type, depth of invasion, lymph node metastasis, and TNM stage in gastric adenoma and gastric adenocarc...
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| Veröffentlicht in: | The Korean journal of gastroenterology 2007-03, Vol.49 (3), p.152 |
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| container_title | The Korean journal of gastroenterology |
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| creator | Lee, Seung Woo Kang, Sang Beom Kim, Yon Soo Nam, Soon Woo Lee, Dong Soo Lee, Hye Kyung Han, Sok Won |
| description | The aim of this study was to investigate the immunohistochemical overexpression of c-erbB-2 and c-met proteins according to the histopathological parameters such as grade of dysplasia, histological type, depth of invasion, lymph node metastasis, and TNM stage in gastric adenoma and gastric adenocarcinoma.
Immunohistochemical staining using monoclonal c-erbB-2 and c-met antibodies was performed on paraffin embedded specimens in 43 adenomas and 44 adenocarcinomas.
The expression rate of c-erbB-2 was higher in adenomas (91%) than adenocarcinomas (30%). The expression rate of c-met was higher in adenocarcinomas (77%) than adenomas (49%). In adenoma, the expression rate of c-met was higher in high grade dysplasia (94%) than in low grade dysplasia (22%). In adenocarcinoma, c-met expression was significantly related with lymph node metastasis.
c-erbB-2 would be involved in the development of relatively early stage gastric carcinogenesis. c-erbB-2 is related with histologic type and c-met with lymph node metastasis in gastric carcinomas. Although meaning for the expression of these proteins in gastric carcinomas would be different, these proteins may play as important oncogenes in gastric carcinogenesis. |
| format | Article |
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Immunohistochemical staining using monoclonal c-erbB-2 and c-met antibodies was performed on paraffin embedded specimens in 43 adenomas and 44 adenocarcinomas.
The expression rate of c-erbB-2 was higher in adenomas (91%) than adenocarcinomas (30%). The expression rate of c-met was higher in adenocarcinomas (77%) than adenomas (49%). In adenoma, the expression rate of c-met was higher in high grade dysplasia (94%) than in low grade dysplasia (22%). In adenocarcinoma, c-met expression was significantly related with lymph node metastasis.
c-erbB-2 would be involved in the development of relatively early stage gastric carcinogenesis. c-erbB-2 is related with histologic type and c-met with lymph node metastasis in gastric carcinomas. Although meaning for the expression of these proteins in gastric carcinomas would be different, these proteins may play as important oncogenes in gastric carcinogenesis.</description><identifier>ISSN: 1598-9992</identifier><identifier>PMID: 18172343</identifier><language>kor</language><publisher>Korea (South)</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Adenoma - metabolism ; Adenoma - pathology ; Aged ; Antibodies, Monoclonal ; Biomarkers, Tumor ; Disease Progression ; Female ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Male ; Middle Aged ; Proto-Oncogene Proteins c-met - immunology ; Proto-Oncogene Proteins c-met - metabolism ; Receptor, ErbB-2 - immunology ; Receptor, ErbB-2 - metabolism ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology</subject><ispartof>The Korean journal of gastroenterology, 2007-03, Vol.49 (3), p.152</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18172343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Seung Woo</creatorcontrib><creatorcontrib>Kang, Sang Beom</creatorcontrib><creatorcontrib>Kim, Yon Soo</creatorcontrib><creatorcontrib>Nam, Soon Woo</creatorcontrib><creatorcontrib>Lee, Dong Soo</creatorcontrib><creatorcontrib>Lee, Hye Kyung</creatorcontrib><creatorcontrib>Han, Sok Won</creatorcontrib><title>Expression of c-erbB-2 and c-met proteins in gastric adenoma and adenocarcinoma</title><title>The Korean journal of gastroenterology</title><addtitle>Korean J Gastroenterol</addtitle><description>The aim of this study was to investigate the immunohistochemical overexpression of c-erbB-2 and c-met proteins according to the histopathological parameters such as grade of dysplasia, histological type, depth of invasion, lymph node metastasis, and TNM stage in gastric adenoma and gastric adenocarcinoma.
Immunohistochemical staining using monoclonal c-erbB-2 and c-met antibodies was performed on paraffin embedded specimens in 43 adenomas and 44 adenocarcinomas.
The expression rate of c-erbB-2 was higher in adenomas (91%) than adenocarcinomas (30%). The expression rate of c-met was higher in adenocarcinomas (77%) than adenomas (49%). In adenoma, the expression rate of c-met was higher in high grade dysplasia (94%) than in low grade dysplasia (22%). In adenocarcinoma, c-met expression was significantly related with lymph node metastasis.
c-erbB-2 would be involved in the development of relatively early stage gastric carcinogenesis. c-erbB-2 is related with histologic type and c-met with lymph node metastasis in gastric carcinomas. Although meaning for the expression of these proteins in gastric carcinomas would be different, these proteins may play as important oncogenes in gastric carcinogenesis.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenoma - metabolism</subject><subject>Adenoma - pathology</subject><subject>Aged</subject><subject>Antibodies, Monoclonal</subject><subject>Biomarkers, Tumor</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proto-Oncogene Proteins c-met - immunology</subject><subject>Proto-Oncogene Proteins c-met - metabolism</subject><subject>Receptor, ErbB-2 - immunology</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><issn>1598-9992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1T8tKAzEUzUKxpfYXJD8QyGsmyVJLfUChm7ouyc2NBJxMyIygf-9YdXWeHDhXZC06Z5lzTq7Idppy4B03ShvrbshKWGGk0mpNjvvP2nDJx0LHRIFhCw9MUl_iIgacaW3jjLlMNBf65qe5ZaA-YhkHf2ldOPgG-ce6JdfJv0-4_cMNeX3cn3bP7HB8etndH1gVUs8sOBMQhA4QFFhlU5B9H23sRXIK-AKad8i1lmCkt9GLmIwH1UWONjmjNuTud7d-hAHjubY8-PZ1_n-mvgG8JUpZ</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Lee, Seung Woo</creator><creator>Kang, Sang Beom</creator><creator>Kim, Yon Soo</creator><creator>Nam, Soon Woo</creator><creator>Lee, Dong Soo</creator><creator>Lee, Hye Kyung</creator><creator>Han, Sok Won</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200703</creationdate><title>Expression of c-erbB-2 and c-met proteins in gastric adenoma and adenocarcinoma</title><author>Lee, Seung Woo ; Kang, Sang Beom ; Kim, Yon Soo ; Nam, Soon Woo ; Lee, Dong Soo ; Lee, Hye Kyung ; Han, Sok Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-b97bec14bcb3c838fb266d8d61f93c061f405e0442c72a8da1df7ac35d0e8f973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2007</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenoma - metabolism</topic><topic>Adenoma - pathology</topic><topic>Aged</topic><topic>Antibodies, Monoclonal</topic><topic>Biomarkers, Tumor</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proto-Oncogene Proteins c-met - immunology</topic><topic>Proto-Oncogene Proteins c-met - metabolism</topic><topic>Receptor, ErbB-2 - immunology</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Seung Woo</creatorcontrib><creatorcontrib>Kang, Sang Beom</creatorcontrib><creatorcontrib>Kim, Yon Soo</creatorcontrib><creatorcontrib>Nam, Soon Woo</creatorcontrib><creatorcontrib>Lee, Dong Soo</creatorcontrib><creatorcontrib>Lee, Hye Kyung</creatorcontrib><creatorcontrib>Han, Sok Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>The Korean journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Seung Woo</au><au>Kang, Sang Beom</au><au>Kim, Yon Soo</au><au>Nam, Soon Woo</au><au>Lee, Dong Soo</au><au>Lee, Hye Kyung</au><au>Han, Sok Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of c-erbB-2 and c-met proteins in gastric adenoma and adenocarcinoma</atitle><jtitle>The Korean journal of gastroenterology</jtitle><addtitle>Korean J Gastroenterol</addtitle><date>2007-03</date><risdate>2007</risdate><volume>49</volume><issue>3</issue><spage>152</spage><pages>152-</pages><issn>1598-9992</issn><abstract>The aim of this study was to investigate the immunohistochemical overexpression of c-erbB-2 and c-met proteins according to the histopathological parameters such as grade of dysplasia, histological type, depth of invasion, lymph node metastasis, and TNM stage in gastric adenoma and gastric adenocarcinoma.
Immunohistochemical staining using monoclonal c-erbB-2 and c-met antibodies was performed on paraffin embedded specimens in 43 adenomas and 44 adenocarcinomas.
The expression rate of c-erbB-2 was higher in adenomas (91%) than adenocarcinomas (30%). The expression rate of c-met was higher in adenocarcinomas (77%) than adenomas (49%). In adenoma, the expression rate of c-met was higher in high grade dysplasia (94%) than in low grade dysplasia (22%). In adenocarcinoma, c-met expression was significantly related with lymph node metastasis.
c-erbB-2 would be involved in the development of relatively early stage gastric carcinogenesis. c-erbB-2 is related with histologic type and c-met with lymph node metastasis in gastric carcinomas. Although meaning for the expression of these proteins in gastric carcinomas would be different, these proteins may play as important oncogenes in gastric carcinogenesis.</abstract><cop>Korea (South)</cop><pmid>18172343</pmid></addata></record> |
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| ispartof | The Korean journal of gastroenterology, 2007-03, Vol.49 (3), p.152 |
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| source | MEDLINE; KoreaMed Open Access; DOAJ Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenoma - metabolism Adenoma - pathology Aged Antibodies, Monoclonal Biomarkers, Tumor Disease Progression Female Humans Immunohistochemistry Lymphatic Metastasis Male Middle Aged Proto-Oncogene Proteins c-met - immunology Proto-Oncogene Proteins c-met - metabolism Receptor, ErbB-2 - immunology Receptor, ErbB-2 - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - pathology |
| title | Expression of c-erbB-2 and c-met proteins in gastric adenoma and adenocarcinoma |
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