LOC387715/HTRA1 and Complement Factor H Variants in Patients with Age-Related Macular Degeneration Seen at the Mayo Clinic

LOC387715/HTRA1 and Complement Factor H Variants in Patients with Age-Related Macular Degeneration Seen at the Mayo Clinic

Purpose: To confirm association of the complement factor H allelic variant (CFH Y402H) and the LOC387715/HTRA1 (LOC387715 A69S) risk alleles with age-related macular degeneration (AMD). Study Population: Study of 89 Caucasian patients with neovascular (exudative) AMD and 232 Caucasian controls.Metho...

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Veröffentlicht in:Ophthalmic genetics 2007-12, Vol.28 (4), p.203-207
Hauptverfasser: Pulido, Jose S., Peterson, Lisa M., Mutapcic, Lejla, Bryant, Sandra, Highsmith, W. Edward
Format: Artikel
Sprache:eng
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Age-related macular degeneration
association study
Base Sequence
Complement Factor H - genetics
complement H
DNA Primers
Genetic Predisposition to Disease
genetics
Humans
Macular Degeneration - genetics
Minnesota
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
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container_end_page 207
container_issue 4
container_start_page 203
container_title Ophthalmic genetics
container_volume 28
creator Pulido, Jose S.
Peterson, Lisa M.
Mutapcic, Lejla
Bryant, Sandra
Highsmith, W. Edward
description Purpose: To confirm association of the complement factor H allelic variant (CFH Y402H) and the LOC387715/HTRA1 (LOC387715 A69S) risk alleles with age-related macular degeneration (AMD). Study Population: Study of 89 Caucasian patients with neovascular (exudative) AMD and 232 Caucasian controls.Methods: The Y402H variant of CFH gene and A69S variant of LOC387715/HTRA1 gene locus were examined.Results: For CFH, the odds ratio for the homozygous variant was 4.97 (CI 2.52 to 9.79). For LOC387715/HTRA1 the odds ratio for the homozygous risk variant was 7.75 (CI 3.46 to 17.35). The odds ratio for heterozygous carriers was 3.35 (CI 1.91 to 5.90).
doi_str_mv 10.1080/13816810701649617
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source MEDLINE; Taylor & Francis; Taylor & Francis Medical Library - CRKN
subjects Age-related macular degeneration
association study
Base Sequence
Complement Factor H - genetics
complement H
DNA Primers
Genetic Predisposition to Disease
genetics
Humans
Macular Degeneration - genetics
Minnesota
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
title LOC387715/HTRA1 and Complement Factor H Variants in Patients with Age-Related Macular Degeneration Seen at the Mayo Clinic
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