Synergistic effect of mTOR inhibitor rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with an annual occurrence of one million new cases. At present there is no effective treatment for HCC individuals that not amenable to curative therapies. Recent studies show the PI3K/Akt/mTOR signal pathway is involved...

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Veröffentlicht in:	Cancer biology & therapy 2008-03, Vol.7 (3), p.392-396
Hauptverfasser:	Bu, Xinxin, Le, Chen, Jia, Fengqi, Guo, Xianling, Zhang, Li, Wu, Mengchao, Wei, Lixin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - physiology Binding Biology Bioscience Calcium Cancer Carcinoma, Hepatocellular - pathology Cell Cell Line, Tumor Cellular Senescence - drug effects Cellular Senescence - physiology Cycle Fluorouracil - pharmacology Humans Landes Liver Neoplasms - pathology Organogenesis Protein Kinases Proteins Sirolimus - pharmacology TOR Serine-Threonine Kinases
Online-Zugang:	Volltext
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