In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation

The prolongation of the ventricular repolarization and proarrhythmic effects (Torsade de Pointes: TdP) of five reference antibiotics were compared in four in-vitro models. 1. Using the patch clamp technique on the human ether-a-gogo-related gene (HERG) current, the rank order for blockade of the HER...

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Veröffentlicht in:	European journal of pharmacology 2007-12, Vol.577 (1-3), p.222
Hauptverfasser:	Lu, Hua Rong, Vlaminckx, Eddy, Van de Water, Andre, Rohrbacher, Jutta, Hermans, An, Gallacher, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - blood Electrophysiology ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels - drug effects Heart Ventricles - drug effects Humans In Vitro Techniques Long QT Syndrome - chemically induced Long QT Syndrome - physiopathology Membrane Potentials - drug effects Patch-Clamp Techniques Purkinje Fibers - drug effects Rabbits Risk Assessment Torsades de Pointes - chemically induced Torsades de Pointes - physiopathology Ventricular Function, Left - drug effects
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