SacB Mutagenesis Strategy Reveals that the Bartonella quintana Variably Expressed Outer Membrane Proteins Are Required for Bloodstream Infection of the Host

Bartonella bacteria adhere to erythrocytes and persistently infect the mammalian bloodstream. We previously identified four highly conserved Bartonella quintana adhesin genes that undergo phase variation during prolonged bloodstream infection. The variably expressed outer membrane proteins (Vomp) en...

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Veröffentlicht in:	Infection and Immunity 2008-02, Vol.76 (2), p.788-795
Hauptverfasser:	MacKichan, Joanna K, Gerns, Helen L, Chen, Yu-Ting, Zhang, Peng, Koehler, Jane E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - genetics Adhesins, Bacterial - physiology Animals Bacteremia - microbiology Bacterial diseases Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - physiology Bacterial sepsis Bacteriology Bartonella Bartonella quintana Bartonella quintana - genetics Bartonella quintana - pathogenicity Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene Deletion Human bacterial diseases Infectious diseases Macaca mulatta Medical sciences Microbiology Miscellaneous Molecular Pathogenesis Mutagenesis Trench Fever - microbiology Virulence Factors - genetics Virulence Factors - physiology
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