Streptochlorin, a marine natural product, inhibits NF-kappaB activation and suppresses angiogenesis in vitro

Angiogenesis is an essential step in tumor progress and metastasis. Accordingly, small molecules that inhibit angiogenesis would appear to be a promising way to cure angiogenesis-related diseases, including cancer. In the present study, we report that streptochlorin, a small molecule from marine act...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2007-08, Vol.17 (8), p.1338
Hauptverfasser:	Choi, In-Kwon, Shin, Hee Jae, Lee, Hyi-Seung, Kwon, Ho Jeong
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinobacteria - chemistry Angiogenesis Inhibitors - isolation & purification Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - toxicity Cell Line Cell Proliferation - drug effects Endothelial Cells - drug effects Humans Immunologic Factors - isolation & purification Immunologic Factors - pharmacology Immunologic Factors - toxicity Indoles - isolation & purification Indoles - pharmacology Indoles - toxicity NF-kappa B - antagonists & inhibitors Oxazoles - isolation & purification Oxazoles - pharmacology Oxazoles - toxicity
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