Comparative Molecular Field Analysis of Quinoline Derivatives as Selective and Noncompetitive mGluR1 Antagonists

A 3D- QSAR model os Comparative Molecular Field Analysib (CoMFA) of 45 quinoline derivatives as metaborropic glutamate receptor subtype 1 (mGluR1) inhibitors wew investigated. The CoMFA analysis provided a model with q² value of 0.827 and r² value of 0.990, in which q² value of 0.827 and an r² value...

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Veröffentlicht in:	Chemical biology & drug design 2007-12, Vol.70 (6), p.511-519
Hauptverfasser:	Nataraja Sekhar, Y, Ravi Shashi Nayana, M, Ravikumar, Muttineni, Mahmood, S.k
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Design Mice Models, Molecular Quinolines - chemistry Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - chemistry Software Structure-Activity Relationship
Online-Zugang:	Volltext
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