Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases

Covalent modifications of histones, such as acetylation and methylation, play important roles in the regulation of gene expression. Histone lysine methylation has been implicated in both gene activation and repression, depending on the specific lysine (K) residue that becomes methylated and the stat...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-11, Vol.104 (47), p.18439-18444
Hauptverfasser:	Hong, SunHwa, Cho, Young-Wook, Yu, Li-Rong, Yu, Hong, Veenstra, Timothy D, Ge, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibodies Biochemistry Biological Sciences Catalysis Cell Line Cell lines Chlorocebus aethiops COS cells Gene expression Gene expression regulation Gene Expression Regulation, Enzymologic Gene silencing Genes Histone Demethylases Histones Histones - metabolism Humans Jumonji Domain-Containing Histone Demethylases Lysine - genetics Lysine - metabolism Methylation Mice Mutation - genetics Nuclear Proteins - genetics Nuclear Proteins - metabolism Oxidoreductases, N-Demethylating - genetics Oxidoreductases, N-Demethylating - metabolism Plasmids Protein Structure, Tertiary Proteins Substrate Specificity Transcriptional Activation
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