Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB

The dietary antioxidant Curcumin has been proposed for cancer chemoprevention since it induces apoptosis and inhibits the formation of breast cancer metastases. Curcumin acts through the inhibition of phosphorylation of the inhibitor of kappa B (IkappaB), which in turn reduces the nuclear translocat...

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Veröffentlicht in:	Carcinogenesis (New York) 2008-04, Vol.29 (4), p.779
Hauptverfasser:	Bachmeier, Beatrice E, Mohrenz, Isabelle V, Mirisola, Valentina, Schleicher, Erwin, Romeo, Francesco, Höhneke, Clara, Jochum, Marianne, Nerlich, Andreas G, Pfeffer, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Breast Neoplasms - genetics Cell Line, Tumor Chemokine CXCL1 - genetics Chemokine CXCL2 - genetics Curcumin - pharmacology DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification Down-Regulation - drug effects Female Humans Mice Mice, Nude NF-kappa B - physiology Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction RNA, Neoplasm - genetics RNA, Neoplasm - isolation & purification Transplantation, Heterologous
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