Homocysteine stimulates monocyte chemoattractant protein-1 expression in the kidney via nuclear factor-kappaB activation

Hyperhomocysteinemia, or an elevation of blood homocysteine (Hcy) levels, is associated with cardiovascular disorders. Although kidney dysfunction is an important risk factor causing hyperhomocysteinemia, the direct effect of Hcy on the kidney is not well documented. There is a positive association...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2008-01, Vol.294 (1), p.F236
Hauptverfasser:	Hwang, Sun-Young, Woo, Connie W H, Au-Yeung, Kathy K W, Siow, Yaw L, Zhu, Tong Y, O, Karmin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Homocysteine - metabolism Homocysteine - pharmacology Humans Hyperhomocysteinemia - chemically induced Hyperhomocysteinemia - metabolism Hyperhomocysteinemia - pathology Kidney - metabolism Kidney - pathology Kidney Tubules, Proximal - metabolism Kidney Tubules, Proximal - pathology Male Methionine NF-kappa B - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - metabolism
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