Solubilization of components of outer membrane of Leptospira interrogans serovar mozdok by sodium desoxycholate and triton X-100 and evaluation of their immunogenic capacity and homologous and heterologous protection induced in hamsters
Two detergents (triton X-100 and sodium desoxycholate) were evaluated as solubilizing agents of the components of the outer membrane of Leptospira Pomona serovar mozdok. It was obtained a greater yielding of proteins on applying the treatment with triton X-100. The variants formulated starting from...
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| Veröffentlicht in: | Revista cubana de medicina tropical 2005-01, Vol.57 (1), p.53 |
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| container_title | Revista cubana de medicina tropical |
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| creator | Rivera, Yovania Fernández Navarro, Yadira Pino Mazorra, Yisabel Aranguren Rodríguez, Andrés González Padrón, María de los Angeles Valdés, Yolanda |
| description | Two detergents (triton X-100 and sodium desoxycholate) were evaluated as solubilizing agents of the components of the outer membrane of Leptospira Pomona serovar mozdok. It was obtained a greater yielding of proteins on applying the treatment with triton X-100. The variants formulated starting from the extracts obtained showed a high immunogenicity and capacity of homologous protection against the challenge in hamster. |
| format | Article |
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The variants formulated starting from the extracts obtained showed a high immunogenicity and capacity of homologous protection against the challenge in hamster.</description><subject>Animals</subject><subject>Antibodies, Bacterial - blood</subject><subject>Bacterial Outer Membrane Proteins - immunology</subject><subject>Bacterial Vaccines - immunology</subject><subject>Cricetinae</subject><subject>Deoxycholic Acid - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Leptospira interrogans - immunology</subject><subject>Leptospira interrogans - pathogenicity</subject><subject>Leptospira interrogans serovar canicola - immunology</subject><subject>Leptospirosis - immunology</subject><subject>Leptospirosis - prevention & control</subject><subject>Lethal Dose 50</subject><subject>Octoxynol - pharmacology</subject><issn>0375-0760</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOw0AMRbMA0fL4BeQfiDR9kNA1ArFgBwt2lTPjNobMeDSPivSb-QjSQLtldXWvj-wrnxVTtajvSlVXalJcxvih1Hy5Ws4vismsXlXV8l5Ni-9X6XLDHe8xsTiQDWixXhy5FA9OcqIAlmwT0NEheSGfJHoOCOyGYZAtugiRguxwQGVv5BOaHqIYzhYMRfnqdSsdJgJ0BlLgNNx6L2dKjQHtsMunAqklDsDWZidbcqxBo0fNqR_hVqx0spUcfy0NHY6BD5JIj4vYmazJDAot2jhA8bo432AX6eZPr4rbp8e3h-fS58aSWfvAFkO_Pr5n8S_wA3nKeLs</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Rivera, Yovania Fernández</creator><creator>Navarro, Yadira Pino</creator><creator>Mazorra, Yisabel Aranguren</creator><creator>Rodríguez, Andrés González</creator><creator>Padrón, María de los Angeles</creator><creator>Valdés, Yolanda</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200501</creationdate><title>Solubilization of components of outer membrane of Leptospira interrogans serovar mozdok by sodium desoxycholate and triton X-100 and evaluation of their immunogenic capacity and homologous and heterologous protection induced in hamsters</title><author>Rivera, Yovania Fernández ; Navarro, Yadira Pino ; Mazorra, Yisabel Aranguren ; Rodríguez, Andrés González ; Padrón, María de los Angeles ; Valdés, Yolanda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_179664803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antibodies, Bacterial - blood</topic><topic>Bacterial Outer Membrane Proteins - immunology</topic><topic>Bacterial Vaccines - immunology</topic><topic>Cricetinae</topic><topic>Deoxycholic Acid - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Leptospira interrogans - immunology</topic><topic>Leptospira interrogans - pathogenicity</topic><topic>Leptospira interrogans serovar canicola - immunology</topic><topic>Leptospirosis - immunology</topic><topic>Leptospirosis - prevention & control</topic><topic>Lethal Dose 50</topic><topic>Octoxynol - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>Rivera, Yovania Fernández</creatorcontrib><creatorcontrib>Navarro, Yadira Pino</creatorcontrib><creatorcontrib>Mazorra, Yisabel Aranguren</creatorcontrib><creatorcontrib>Rodríguez, Andrés González</creatorcontrib><creatorcontrib>Padrón, María de los Angeles</creatorcontrib><creatorcontrib>Valdés, Yolanda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Revista cubana de medicina tropical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rivera, Yovania Fernández</au><au>Navarro, Yadira Pino</au><au>Mazorra, Yisabel Aranguren</au><au>Rodríguez, Andrés González</au><au>Padrón, María de los Angeles</au><au>Valdés, Yolanda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solubilization of components of outer membrane of Leptospira interrogans serovar mozdok by sodium desoxycholate and triton X-100 and evaluation of their immunogenic capacity and homologous and heterologous protection induced in hamsters</atitle><jtitle>Revista cubana de medicina tropical</jtitle><addtitle>Rev Cubana Med Trop</addtitle><date>2005-01</date><risdate>2005</risdate><volume>57</volume><issue>1</issue><spage>53</spage><pages>53-</pages><issn>0375-0760</issn><abstract>Two detergents (triton X-100 and sodium desoxycholate) were evaluated as solubilizing agents of the components of the outer membrane of Leptospira Pomona serovar mozdok. 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| fulltext | fulltext |
| identifier | ISSN: 0375-0760 |
| ispartof | Revista cubana de medicina tropical, 2005-01, Vol.57 (1), p.53 |
| issn | 0375-0760 |
| language | spa |
| recordid | cdi_pubmed_primary_17966480 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antibodies, Bacterial - blood Bacterial Outer Membrane Proteins - immunology Bacterial Vaccines - immunology Cricetinae Deoxycholic Acid - pharmacology Disease Models, Animal Leptospira interrogans - immunology Leptospira interrogans - pathogenicity Leptospira interrogans serovar canicola - immunology Leptospirosis - immunology Leptospirosis - prevention & control Lethal Dose 50 Octoxynol - pharmacology |
| title | Solubilization of components of outer membrane of Leptospira interrogans serovar mozdok by sodium desoxycholate and triton X-100 and evaluation of their immunogenic capacity and homologous and heterologous protection induced in hamsters |
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