Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation

Triggering of antigen receptors on lymphocytes is critical for initiating adaptive immune response against pathogens. T-cell receptor (TCR) engagement induces the formation of the Carma1-Bcl10-Malt1 (CBM) complex that is essential for activation of the IkappaB kinase (IKK)/NF-kappaB pathway. However...

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Veröffentlicht in:	The EMBO journal 2007-11, Vol.26 (22), p.4634
Hauptverfasser:	Oeckinghaus, Andrea, Wegener, Elmar, Welteke, Verena, Ferch, Uta, Arslan, Seda Cöl, Ruland, Jürgen, Scheidereit, Claus, Krappmann, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Apoptosis Regulatory Proteins - metabolism B-Cell CLL-Lymphoma 10 Protein CARD Signaling Adaptor Proteins - metabolism Caspases - metabolism Cell Line Guanylate Cyclase - metabolism Humans I-kappa B Kinase - metabolism Interleukin-2 - metabolism Jurkat Cells Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein Neoplasm Proteins - metabolism NF-kappa B - metabolism T-Lymphocytes - metabolism TNF Receptor-Associated Factor 6 - metabolism Ubiquitination
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