Crystal Structure of the ECH₂ Catalytic Domain of CurF from Lyngbya majuscula: INSIGHTS INTO A DECARBOXYLASE INVOLVED IN POLYKETIDE CHAIN β-BRANCHING

Curacin A is a mixed polyketide/nonribosomal peptide possessing anti-mitotic and anti-proliferative activity. In the biosynthesis of curacin A, the N-terminal domain of the CurF multifunctional protein catalyzes decarboxylation of 3-methylglutaconyl-acyl carrier protein (ACP) to 3-methylcrotonyl-ACP...

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Veröffentlicht in:	The Journal of biological chemistry 2007-12, Vol.282 (49), p.35954-35963
Hauptverfasser:	Geders, Todd W, Gu, Liangcai, Mowers, Jonathan C, Liu, Haichuan, Gerwick, William H, Håkansson, Kristina, Sherman, David H, Smith, Janet L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Bacterial Proteins - chemistry Bacterial Proteins - genetics Binding Sites - genetics Carboxy-Lyases - chemistry Carboxy-Lyases - metabolism Catalytic Domain Crystallography, X-Ray Cyanobacteria - enzymology Cyanobacteria - genetics Cyclopropanes - metabolism Enoyl-CoA Hydratase - chemistry Enoyl-CoA Hydratase - genetics Macrolides - metabolism Mutagenesis, Site-Directed Mutation, Missense Substrate Specificity - genetics Thiazoles - metabolism
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