Pivotal involvement of Fcgamma receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1

The mammalian Toll-like receptor (TLR) family has evolved to sense pathogens in the environment and protect the host against infection. TLR4 recognizes lipopolysaccharide (LPS) from Gram-negative bacteria and induces a signaling cascade that, when exaggerated, has been associated with severe sepsis....

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Veröffentlicht in:	The Journal of biological chemistry 2007-11, Vol.282 (48), p.34817
Hauptverfasser:	Dunn-Siegrist, Irene, Leger, Olivier, Daubeuf, Bruno, Poitevin, Yves, Dépis, Fabien, Herren, Suzanne, Kosco-Vilbois, Marie, Dean, Yann, Pugin, Jérôme, Elson, Greg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Antigens, CD - biosynthesis Antigens, CD - chemistry Cell Line Cells, Cultured Cloning, Molecular Dose-Response Relationship, Drug Endothelium, Vascular - metabolism Epitopes - chemistry Humans Lipopolysaccharides - chemistry Lipopolysaccharides - metabolism Mice Mice, Inbred BALB C Polymorphism, Genetic Receptors, IgG - biosynthesis Receptors, IgG - chemistry Signal Transduction Toll-Like Receptor 4 - chemistry Toll-Like Receptor 4 - metabolism
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