Inhibition of nuclear factor-kappaB in T cells suppresses lung fibrosis

Cytokines secreted by T cells play a pivotal role in the pathogenesis of lung injury and fibrosis, and the transcription factors nuclear factor (NF)-kappaB and activator protein (AP)-1 are involved in the expression of cytokines from T cells during lung injury. We assessed the potential therapeutic...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2007-12, Vol.176 (12), p.1251
Hauptverfasser:	Fujimoto, Hajime, D'Alessandro-Gabazza, Corina N, Palanki, Moorthy S S, Erdman, Paul E, Takagi, Takehiro, Gabazza, Esteban C, Bruno, Nelson E, Yano, Yutaka, Hayashi, Tatsuya, Tamaki, Shigenori, Sumida, Yasuhiro, Adachi, Yukihiko, Suzuki, Koji, Taguchi, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bronchoalveolar Lavage Fluid - cytology Disease Models, Animal Dose-Response Relationship, Drug Female Humans Immunosuppressive Agents - pharmacology Jurkat Cells Mice NF-kappa B - drug effects Organic Chemicals - pharmacology Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - drug therapy T-Lymphocytes - drug effects
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