Methotrexate-induced mucositis in acute leukemia patients is not associated with the MTHFR 677T allele in Mexico

Methylenetetrahydrofolate reductase (MTHFR) has two common variants with reduced activity due to polymorphisms at nucleotides 677 and 1298. Both affect folate metabolism and thus remethylation of homocysteine, but are also thought to affect nucleotide synthesis and DNA methylation. Methotrexate (MTX...

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Veröffentlicht in:	Hematology (Luxembourg) 2007-10, Vol.12 (5), p.387-391
Hauptverfasser:	Ruiz-Argüelles, Guillermo J., Nancy Coconi-Linares, Lucia, Garcés-Eisele, Javier, Reyes-Núñez, Virginia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alleles Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - therapeutic use Child Child, Preschool Diet Female Folic Acid - metabolism GENETIC POLYMORPHISMS Humans Infant Infant, Newborn Male METHOTREXATE Methotrexate - adverse effects Methotrexate - therapeutic use Methylenetetrahydrofolate Reductase (NADPH2) - genetics Methylenetetrahydrofolate Reductase (NADPH2) - metabolism MEXICO Mexico - epidemiology MTHFR MUCOSITIS Mucositis - chemically induced Mucositis - epidemiology Mucositis - genetics Polymorphism, Single Nucleotide Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Risk Factors
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