Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demons...
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| Veröffentlicht in: | Drug development and industrial pharmacy 2007-01, Vol.33 (9), p.909-926 |
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| container_title | Drug development and industrial pharmacy |
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| creator | Crowley, Michael M. Zhang, Feng Repka, Michael A. Thumma, Sridhar Upadhye, Sampada B. Kumar Battu, Sunil McGinity, James W. Martin, Charles |
| description | Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants. |
| doi_str_mv | 10.1080/03639040701498759 |
| format | Article |
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Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.1080/03639040701498759</identifier><identifier>PMID: 17891577</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>bioavailability ; Biological and medical sciences ; Chemical Phenomena ; Chemistry, Physical ; Delayed-Action Preparations ; Dosage Forms ; Drug Carriers - chemistry ; Drug Compounding - instrumentation ; Drug Compounding - methods ; drug delivery systems ; Drug Industry ; Excipients - chemistry ; extruder ; General pharmacology ; Hot Temperature ; immediate release ; Medical sciences ; melt extrusion ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; solid dispersion ; solid molecular dispersion ; sustained release ; Technology, Pharmaceutical - instrumentation ; Technology, Pharmaceutical - methods ; thermal processing</subject><ispartof>Drug development and industrial pharmacy, 2007-01, Vol.33 (9), p.909-926</ispartof><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-53e3ef1cc4c3df556fdacd8e3b7735a57db94c09054f83d5689a00bfe906a6d53</citedby><cites>FETCH-LOGICAL-c500t-53e3ef1cc4c3df556fdacd8e3b7735a57db94c09054f83d5689a00bfe906a6d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/03639040701498759$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/03639040701498759$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19133487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17891577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crowley, Michael M.</creatorcontrib><creatorcontrib>Zhang, Feng</creatorcontrib><creatorcontrib>Repka, Michael A.</creatorcontrib><creatorcontrib>Thumma, Sridhar</creatorcontrib><creatorcontrib>Upadhye, Sampada B.</creatorcontrib><creatorcontrib>Kumar Battu, Sunil</creatorcontrib><creatorcontrib>McGinity, James W.</creatorcontrib><creatorcontrib>Martin, Charles</creatorcontrib><title>Pharmaceutical Applications of Hot-Melt Extrusion: Part I</title><title>Drug development and industrial pharmacy</title><addtitle>Drug Dev Ind Pharm</addtitle><description>Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.</description><subject>bioavailability</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Delayed-Action Preparations</subject><subject>Dosage Forms</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Compounding - instrumentation</subject><subject>Drug Compounding - methods</subject><subject>drug delivery systems</subject><subject>Drug Industry</subject><subject>Excipients - chemistry</subject><subject>extruder</subject><subject>General pharmacology</subject><subject>Hot Temperature</subject><subject>immediate release</subject><subject>Medical sciences</subject><subject>melt extrusion</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>solid dispersion</subject><subject>solid molecular dispersion</subject><subject>sustained release</subject><subject>Technology, Pharmaceutical - instrumentation</subject><subject>Technology, Pharmaceutical - methods</subject><subject>thermal processing</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFPwjAYhhujEUR_gBezi96mX-m6ruqFEFQSjBz0vJSuDSNlxbaL8u8tAUOMCac27fO--b4HoUsMtxgKuAOSEw4ZMMAZLxjlR6iLaR9SyvL-Mepu_tMI0A46834BgPuc0lPUwazgmDLWRXw6F24ppGpDLYVJBquViZdQ28YnVicvNqSvyoRk9B1c6-PzfTIVLiTjc3SihfHqYnf20MfT6H34kk7ensfDwSSVFCCklCiiNJYyk6TSlOa6ErIqFJkxRqigrJrxTAIHmumCVDQvuACYacUhF3lFSQ_dbHtXzn62yodyWXupjBGNsq0v84JA3icQQbwFpbPeO6XLlauXwq1LDOXGV_nPV8xc7crb2VJV-8ROUASud4Dw0Y92opG133McE5IVG-5xy9WNtlHol3WmKoNYG-t-Q-TQHA9_4nMlTJhL4VS5sK1rouADW_wAflyW1g</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Crowley, Michael M.</creator><creator>Zhang, Feng</creator><creator>Repka, Michael A.</creator><creator>Thumma, Sridhar</creator><creator>Upadhye, Sampada B.</creator><creator>Kumar Battu, Sunil</creator><creator>McGinity, James W.</creator><creator>Martin, Charles</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Pharmaceutical Applications of Hot-Melt Extrusion: Part I</title><author>Crowley, Michael M. ; Zhang, Feng ; Repka, Michael A. ; Thumma, Sridhar ; Upadhye, Sampada B. ; Kumar Battu, Sunil ; McGinity, James W. ; Martin, Charles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-53e3ef1cc4c3df556fdacd8e3b7735a57db94c09054f83d5689a00bfe906a6d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>bioavailability</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Delayed-Action Preparations</topic><topic>Dosage Forms</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Compounding - instrumentation</topic><topic>Drug Compounding - methods</topic><topic>drug delivery systems</topic><topic>Drug Industry</topic><topic>Excipients - chemistry</topic><topic>extruder</topic><topic>General pharmacology</topic><topic>Hot Temperature</topic><topic>immediate release</topic><topic>Medical sciences</topic><topic>melt extrusion</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. 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Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. 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| ispartof | Drug development and industrial pharmacy, 2007-01, Vol.33 (9), p.909-926 |
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| source | Taylor & Francis; MEDLINE; Taylor & Francis Medical Library - CRKN; Business Source Complete |
| subjects | bioavailability Biological and medical sciences Chemical Phenomena Chemistry, Physical Delayed-Action Preparations Dosage Forms Drug Carriers - chemistry Drug Compounding - instrumentation Drug Compounding - methods drug delivery systems Drug Industry Excipients - chemistry extruder General pharmacology Hot Temperature immediate release Medical sciences melt extrusion Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments solid dispersion solid molecular dispersion sustained release Technology, Pharmaceutical - instrumentation Technology, Pharmaceutical - methods thermal processing |
| title | Pharmaceutical Applications of Hot-Melt Extrusion: Part I |
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