Herpes simplex virus type 2 infections of the central nervous system: A retrospective study of 49 patients
Herpes simplex virus type 2 (HSV-2) infections of the central nervous system (CNS) are rare with meningitis as the most common clinical presentation. We have investigated the clinical spectrum of CNS infections in 49 adult consecutive patients with HSV-2 genome in the cerebrospinal fluid (CSF). HSV-...
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| Veröffentlicht in: | Scandinavian journal of infectious diseases 2008, Vol.40 (1), p.59-62 |
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| creator | Haukali Omland, Lars Faber Vestergaard, Bent Heugh Wandall, Johan |
| description | Herpes simplex virus type 2 (HSV-2) infections of the central nervous system (CNS) are rare with meningitis as the most common clinical presentation. We have investigated the clinical spectrum of CNS infections in 49 adult consecutive patients with HSV-2 genome in the cerebrospinal fluid (CSF). HSV-2 in the CSF was determined by polymerase chain reaction (PCR), and patients were diagnosed as encephalitis or meningitis according to predefined clinical criteria by retrospective data information from consecutive clinical journals. The annual crude incidence rate of HSV-2 CNS disease was 0.26 per 100,000. 43 (88%) had meningitis of whom 8 (19%) had recurring lymphocytic meningitis. Six patients (12%) had encephalitis. 11 of 49 patients (22%) had sequelae recorded during follow-up. None died as a result of HSV-2 CNS disease. Thus, the clinical presentation of HSV-2 infection of the CNS is mainly meningitis but encephalitis does occur and neurological sequelae are common. Recurring lymphocytic meningitis is associated with reactivation of HSV-2 and the condition might be underdiagnosed. |
| doi_str_mv | 10.1080/00365540701509881 |
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We have investigated the clinical spectrum of CNS infections in 49 adult consecutive patients with HSV-2 genome in the cerebrospinal fluid (CSF). HSV-2 in the CSF was determined by polymerase chain reaction (PCR), and patients were diagnosed as encephalitis or meningitis according to predefined clinical criteria by retrospective data information from consecutive clinical journals. The annual crude incidence rate of HSV-2 CNS disease was 0.26 per 100,000. 43 (88%) had meningitis of whom 8 (19%) had recurring lymphocytic meningitis. Six patients (12%) had encephalitis. 11 of 49 patients (22%) had sequelae recorded during follow-up. None died as a result of HSV-2 CNS disease. Thus, the clinical presentation of HSV-2 infection of the CNS is mainly meningitis but encephalitis does occur and neurological sequelae are common. 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We have investigated the clinical spectrum of CNS infections in 49 adult consecutive patients with HSV-2 genome in the cerebrospinal fluid (CSF). HSV-2 in the CSF was determined by polymerase chain reaction (PCR), and patients were diagnosed as encephalitis or meningitis according to predefined clinical criteria by retrospective data information from consecutive clinical journals. The annual crude incidence rate of HSV-2 CNS disease was 0.26 per 100,000. 43 (88%) had meningitis of whom 8 (19%) had recurring lymphocytic meningitis. Six patients (12%) had encephalitis. 11 of 49 patients (22%) had sequelae recorded during follow-up. None died as a result of HSV-2 CNS disease. Thus, the clinical presentation of HSV-2 infection of the CNS is mainly meningitis but encephalitis does occur and neurological sequelae are common. Recurring lymphocytic meningitis is associated with reactivation of HSV-2 and the condition might be underdiagnosed.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Denmark - epidemiology</subject><subject>Encephalitis, Herpes Simplex - cerebrospinal fluid</subject><subject>Encephalitis, Herpes Simplex - epidemiology</subject><subject>Female</subject><subject>Herpes simplex virus 2</subject><subject>Herpesvirus 2, Human - pathogenicity</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meningitis, Viral - cerebrospinal fluid</subject><subject>Meningitis, Viral - epidemiology</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Viral diseases</subject><subject>Viral diseases of the nervous system</subject><issn>0036-5548</issn><issn>1651-1980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EotvCD-CCfIFbYPyV2MClqihFqsQFzpHXmWizcuJgOwv593i1Cwgh9TI-zPOMXr-EvGDwhoGGtwCiVkpCA0yB0Zo9IhtWK1Yxo-Ex2Rz3VQH0BblMaQ8AshbwlFywRituGGzI_g7jjImmYZw9_qSHIS6J5nVGyukw9ejyEKZEQ0_zDqnDKUfr6YTxEAqY1pRxfEevacQcQ5qP_AFpyku3HiVp6GzzULT0jDzprU_4_PxekW-3H7_e3FX3Xz59vrm-r5wUMlcSOe9FUxvLt1ptddczgDJ0A0o5yww4yTrNhWmkdhx6y4VqWCM6VXdWSnFFXp_uzjF8XzDldhySQ-_thCVzy0E1IEAUkJ1AV5KniH07x2G0cW0ZtMeC2_8KLs7L8_FlO2L31zg3WoBXZ8AmZ30f7eSG9IfjAJoxYwr34cSVkkMc7Y8Qfddmu_oQf0vioRzv_9F3aH3eORux3YclTqXgB37xC2oOp5A</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Haukali Omland, Lars</creator><creator>Faber Vestergaard, Bent</creator><creator>Heugh Wandall, Johan</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>2008</creationdate><title>Herpes simplex virus type 2 infections of the central nervous system: A retrospective study of 49 patients</title><author>Haukali Omland, Lars ; Faber Vestergaard, Bent ; Heugh Wandall, Johan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-4e22f3769a2b85b8df100df187055ca190c41d8239748c20fa2357173d56da443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Denmark - epidemiology</topic><topic>Encephalitis, Herpes Simplex - cerebrospinal fluid</topic><topic>Encephalitis, Herpes Simplex - epidemiology</topic><topic>Female</topic><topic>Herpes simplex virus 2</topic><topic>Herpesvirus 2, Human - pathogenicity</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meningitis, Viral - cerebrospinal fluid</topic><topic>Meningitis, Viral - epidemiology</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Viral diseases</topic><topic>Viral diseases of the nervous system</topic><toplevel>online_resources</toplevel><creatorcontrib>Haukali Omland, Lars</creatorcontrib><creatorcontrib>Faber Vestergaard, Bent</creatorcontrib><creatorcontrib>Heugh Wandall, Johan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Scandinavian journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haukali Omland, Lars</au><au>Faber Vestergaard, Bent</au><au>Heugh Wandall, Johan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Herpes simplex virus type 2 infections of the central nervous system: A retrospective study of 49 patients</atitle><jtitle>Scandinavian journal of infectious diseases</jtitle><addtitle>Scand J Infect Dis</addtitle><date>2008</date><risdate>2008</risdate><volume>40</volume><issue>1</issue><spage>59</spage><epage>62</epage><pages>59-62</pages><issn>0036-5548</issn><eissn>1651-1980</eissn><coden>SJIDB7</coden><abstract>Herpes simplex virus type 2 (HSV-2) infections of the central nervous system (CNS) are rare with meningitis as the most common clinical presentation. We have investigated the clinical spectrum of CNS infections in 49 adult consecutive patients with HSV-2 genome in the cerebrospinal fluid (CSF). HSV-2 in the CSF was determined by polymerase chain reaction (PCR), and patients were diagnosed as encephalitis or meningitis according to predefined clinical criteria by retrospective data information from consecutive clinical journals. The annual crude incidence rate of HSV-2 CNS disease was 0.26 per 100,000. 43 (88%) had meningitis of whom 8 (19%) had recurring lymphocytic meningitis. Six patients (12%) had encephalitis. 11 of 49 patients (22%) had sequelae recorded during follow-up. None died as a result of HSV-2 CNS disease. Thus, the clinical presentation of HSV-2 infection of the CNS is mainly meningitis but encephalitis does occur and neurological sequelae are common. Recurring lymphocytic meningitis is associated with reactivation of HSV-2 and the condition might be underdiagnosed.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>17852910</pmid><doi>10.1080/00365540701509881</doi><tpages>4</tpages></addata></record> |
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| ispartof | Scandinavian journal of infectious diseases, 2008, Vol.40 (1), p.59-62 |
| issn | 0036-5548 1651-1980 |
| language | eng |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Adult Biological and medical sciences Denmark - epidemiology Encephalitis, Herpes Simplex - cerebrospinal fluid Encephalitis, Herpes Simplex - epidemiology Female Herpes simplex virus 2 Herpesvirus 2, Human - pathogenicity Human viral diseases Humans Incidence Infectious diseases Male Medical sciences Meningitis, Viral - cerebrospinal fluid Meningitis, Viral - epidemiology Middle Aged Retrospective Studies Viral diseases Viral diseases of the nervous system |
| title | Herpes simplex virus type 2 infections of the central nervous system: A retrospective study of 49 patients |
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