PHARMACOKINETIC AND CLINICAL EVALUATIONS OF FLOMOXEF IN NEONATES

To evaluate pharmacokinetics and clinical effcacy of flomoxef (6315-S, FMOX) in neonates, FMOX was administered to 21 neonates. With 20 mg/kg and 40 mg/kg of intravenous drip-infusion of FMOX 60 minutes, half lives (T1/2's) were 64.9 minutes and 130.3 minutes, respectively, and when 20 mg/kg of...

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Veröffentlicht in:	Japanese journal of antibiotics 1991/11/25, Vol.44(11), pp.1259-1264
Hauptverfasser:	IHARA, TOSHIAKI, KAMIYA, HITOSHI, MATSUDA, TADASHI, SHIMIZU, SHIN, NISHI, HIDEAKI, INAMOCHI, HIDEKI, TAKI, NORIO, SUZUKI, MASAHARU, KOJIMA, MASAMITSU, KAWASAKI, HAJIME, SAKURAI, MINORU
Format:	Artikel
Sprache:	jpn
Schlagworte:	Alanine Transaminase - blood Aspartate Aminotransferases - blood Bacterial Infections - drug therapy Bacterial Infections - metabolism Bacterial Infections - prevention & control Cephalosporins - adverse effects Cephalosporins - pharmacokinetics Cephalosporins - therapeutic use Drug Evaluation Eosinophilia - chemically induced Female Half-Life Humans Infant, Newborn Male
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