Human Equilibrative Nucleoside Transporter 1, as a Predictor of 5-Fluorouracil Resistance in Human Pancreatic Cancer

Background: The purpose of this study was to find a novel biomarker to predict 5-fluorouracil (5-FU) or gemcitabine (2â²,2â²-difluoro-deoxycytidine) sensitivity in pancreatic cancer. Materials and Methods: The relationship between 5-FU and gemcitabine sensitivity and the mRNA levels of human equil...

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Veröffentlicht in:	Anticancer research 2007-07, Vol.27 (4B), p.2241-2249
Hauptverfasser:	TSUJIE, Masanori, NAKAMORI, Shoji, MONDEN, Morito, NAKAHIRA, Shin, TAKAHASHI, Yuji, HAYASHI, Nobuyasu, OKAMI, Jiro, NAGANO, Hiroaki, DONO, Keizo, UMESHITA, Koji, SAKON, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - pharmacology Biological and medical sciences Cell Growth Processes - drug effects Cell Line, Tumor Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Drug Resistance, Neoplasm Drug Screening Assays, Antitumor Equilibrative Nucleoside Transporter 1 - biosynthesis Equilibrative Nucleoside Transporter 1 - genetics Equilibrative Nucleoside Transporter 1 - metabolism Fluorouracil - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Predictive Value of Tests RNA, Messenger - biosynthesis RNA, Messenger - genetics Tumors
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