IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival

Chronic lymphocytic leukemia (CLL) is a malignant disease of small mature lymphocytes. Previous studies have shown that CLL B lymphocytes express relatively large amounts of CD74 mRNA relative to normal B cells. In the present study, we analyzed the molecular mechanism regulated by CD74 in B-CLL cel...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-08, Vol.104 (33), p.13408-13413
Hauptverfasser:	Binsky, Inbal, Haran, Michal, Starlets, Diana, Gore, Yael, Lantner, Frida, Harpaz, Nurit, Leng, Lin, Goldenberg, David M, Shvidel, Lev, Berrebi, Alain, Bucala, Richard, Shachar, Idit
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Amino acids Antibodies Antigens, Differentiation, B-Lymphocyte - physiology Apoptosis B lymphocytes Biological Sciences Blotting, Western Cell adhesion & migration Cell growth Cell Survival Cells Chronic lymphocytic leukemia Epithelial cells Flow Cytometry Gene expression regulation Histocompatibility Antigens Class II - physiology Humans Immunology Interleukin-8 - genetics Interleukin-8 - metabolism Interleukin-8 - physiology Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - pathology Messenger RNA RNA Secretion Signal Transduction
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