Double High-Flux Hemodiafiltration

Hemodiafi ltration (HDF) can augment the effi ciency of removal of small and large solutes for renal replacement therapy. Double high-fl ux HDF was developed in 1984 with the objective to shorten treatment time compared to conventional therapy. It consists of a serial pair of dialyzers in the extracorporeal circuit for optimal diffusion and fi ltration, with substitution by backfi ltration of bicarbonate dialysate under volumetric control. Used in conjunction with high blood and dialysate fl ow rates and high-fl ux membranes, unmatched high rates of simultaneous diffusive and convective solute transport can be obtained clinically with double HDF. A favorable long-term clinical outcome in comparison with conventional hemodialysis was observed with this therapy, despite shorter treatment times.