Ibudilast-induced decreases in cytosolic Ca(2+) level and contraction in rat aorta

The mechanism by which ibudilast induces vasodilation was examined in isolated endothelium-denuded rat aorta. Ibudilast inhibited the contractions induced by phenylephrine (PE) and high K(+) with decrease of [Ca(2+)](i) level in a concentration-dependent manner, to the same degree. 3-Isobutyl-1-meth...

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Veröffentlicht in:	Journal of pharmacological sciences 2007-08, Vol.104 (4), p.311
Hauptverfasser:	Kaneda, Takeharu, Konno, Yasushi, Urakawa, Norimoto, Nakajyo, Shinjiro, Shimizu, Kazumasa
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - administration & dosage 1-Methyl-3-isobutylxanthine - pharmacology Animals Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Calcium - metabolism Cyclic AMP - metabolism Cyclic GMP - metabolism Cytosol - drug effects Cytosol - metabolism Dose-Response Relationship, Drug Male Muscle Contraction - drug effects Muscle Tonus - drug effects Muscle, Smooth, Vascular - metabolism Phenylephrine Phosphodiesterase Inhibitors - administration & dosage Phosphodiesterase Inhibitors - pharmacology Potassium - metabolism Pyridines - administration & dosage Pyridines - pharmacology Rats Rats, Wistar Vasodilator Agents - administration & dosage Vasodilator Agents - pharmacology Verapamil - administration & dosage Verapamil - pharmacology
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