Genetic Variation in Serum Low Density Lipoproteins and Lipid Levels in Man
Combined data from 10 different populations indicate that the serum cholesterol and triglyceride levels are higher in Ag(x-) than in Ag(x+) individuals. Although the differences were relatively small, they became more pronounced with increasing age. The Ag(x) antigen, which is associated with the se...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1976-03, Vol.73 (3), p.937-940 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 940 |
|---|---|
| container_issue | 3 |
| container_start_page | 937 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 73 |
| creator | Berg, Kåre Hames, Curtis Dahlén, Gösta Frick, M. Heikki Krishan, Iqbal |
| description | Combined data from 10 different populations indicate that the serum cholesterol and triglyceride levels are higher in Ag(x-) than in Ag(x+) individuals. Although the differences were relatively small, they became more pronounced with increasing age. The Ag(x) antigen, which is associated with the serum low density lipoprotein, is genetically controlled and the present study therefore has revealed a small but significant effect of a single autosomal locus on lipids implicated in the pathogenesis of atherosclerosis. No explanation of the higher cholesterol and triglyceride levels in Ag(x-) than in Ag (x+) persons is apparent. |
| doi_str_mv | 10.1073/pnas.73.3.937 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmed_primary_176662</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>65542</jstor_id><sourcerecordid>65542</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-3c64269c6f7b4fd211ab2632f1d0c3bdf1a140723e0851c95a5b138f9f50834f3</originalsourceid><addsrcrecordid>eNp9kDuP1DAURi3Ea1goaRBFGugyXPvaTlJQoAUWxCAKHq3lODZ4lbGD7SzsvydhlmVoaHwlf-f4Wh8hDylsKTT4bAo6bxvc4rbD5gbZUOhoLXkHN8kGgDV1yxm_S-7lfA4AnWjhDrlNGykl25B3ZzbY4k31RSevi4-h8qH6aNO8r3bxR_XShuzLZbXzU5xSLNaHXOkwrBd-Oe2FHfOqvNfhPrnl9Jjtg6t5Qj6_fvXp9E29-3D29vTFrjZcQKnRSM5kZ6Rreu4GRqnumUTm6AAG-8FRTTk0DC20gppOaNFTbF3nBLTIHZ6Q54d3p7nf28HYUJIe1ZT8XqdLFbVX_ybBf1Nf44VClIBi8Z9e-Sl-n20uau-zseOog41zVi0iNi2VC1gfQJNizsm66x0U1Nq9WrtXy0S1dL_wj48_9pf-XfZRvFp_wiP7yX9i5eZxLPZnWbhHB-48l5iuQSkEZ_gLqc-gOw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83337816</pqid></control><display><type>article</type><title>Genetic Variation in Serum Low Density Lipoproteins and Lipid Levels in Man</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Berg, Kåre ; Hames, Curtis ; Dahlén, Gösta ; Frick, M. Heikki ; Krishan, Iqbal</creator><creatorcontrib>Berg, Kåre ; Hames, Curtis ; Dahlén, Gösta ; Frick, M. Heikki ; Krishan, Iqbal</creatorcontrib><description>Combined data from 10 different populations indicate that the serum cholesterol and triglyceride levels are higher in Ag(x-) than in Ag(x+) individuals. Although the differences were relatively small, they became more pronounced with increasing age. The Ag(x) antigen, which is associated with the serum low density lipoprotein, is genetically controlled and the present study therefore has revealed a small but significant effect of a single autosomal locus on lipids implicated in the pathogenesis of atherosclerosis. No explanation of the higher cholesterol and triglyceride levels in Ag(x-) than in Ag (x+) persons is apparent.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.73.3.937</identifier><identifier>PMID: 176662</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Age Factors ; Antigens ; Black or African American ; Black People ; Cholesterol - blood ; Cholesterols ; Genes ; Genetic Variation ; Humans ; Lipids ; Lipoproteins ; Lipoproteins, LDL - blood ; Lipoproteins, LDL - immunology ; Medical genetics ; Phenotype ; Phenotypes ; Population mean ; Scandinavian and Nordic Countries ; Serum cholesterol ; T tests ; Triglycerides ; Triglycerides - blood ; United States ; White People</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1976-03, Vol.73 (3), p.937-940</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-3c64269c6f7b4fd211ab2632f1d0c3bdf1a140723e0851c95a5b138f9f50834f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/73/3.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/65542$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/65542$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/176662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berg, Kåre</creatorcontrib><creatorcontrib>Hames, Curtis</creatorcontrib><creatorcontrib>Dahlén, Gösta</creatorcontrib><creatorcontrib>Frick, M. Heikki</creatorcontrib><creatorcontrib>Krishan, Iqbal</creatorcontrib><title>Genetic Variation in Serum Low Density Lipoproteins and Lipid Levels in Man</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Combined data from 10 different populations indicate that the serum cholesterol and triglyceride levels are higher in Ag(x-) than in Ag(x+) individuals. Although the differences were relatively small, they became more pronounced with increasing age. The Ag(x) antigen, which is associated with the serum low density lipoprotein, is genetically controlled and the present study therefore has revealed a small but significant effect of a single autosomal locus on lipids implicated in the pathogenesis of atherosclerosis. No explanation of the higher cholesterol and triglyceride levels in Ag(x-) than in Ag (x+) persons is apparent.</description><subject>Age Factors</subject><subject>Antigens</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Cholesterol - blood</subject><subject>Cholesterols</subject><subject>Genes</subject><subject>Genetic Variation</subject><subject>Humans</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Lipoproteins, LDL - blood</subject><subject>Lipoproteins, LDL - immunology</subject><subject>Medical genetics</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Population mean</subject><subject>Scandinavian and Nordic Countries</subject><subject>Serum cholesterol</subject><subject>T tests</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><subject>United States</subject><subject>White People</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDuP1DAURi3Ea1goaRBFGugyXPvaTlJQoAUWxCAKHq3lODZ4lbGD7SzsvydhlmVoaHwlf-f4Wh8hDylsKTT4bAo6bxvc4rbD5gbZUOhoLXkHN8kGgDV1yxm_S-7lfA4AnWjhDrlNGykl25B3ZzbY4k31RSevi4-h8qH6aNO8r3bxR_XShuzLZbXzU5xSLNaHXOkwrBd-Oe2FHfOqvNfhPrnl9Jjtg6t5Qj6_fvXp9E29-3D29vTFrjZcQKnRSM5kZ6Rreu4GRqnumUTm6AAG-8FRTTk0DC20gppOaNFTbF3nBLTIHZ6Q54d3p7nf28HYUJIe1ZT8XqdLFbVX_ybBf1Nf44VClIBi8Z9e-Sl-n20uau-zseOog41zVi0iNi2VC1gfQJNizsm66x0U1Nq9WrtXy0S1dL_wj48_9pf-XfZRvFp_wiP7yX9i5eZxLPZnWbhHB-48l5iuQSkEZ_gLqc-gOw</recordid><startdate>19760301</startdate><enddate>19760301</enddate><creator>Berg, Kåre</creator><creator>Hames, Curtis</creator><creator>Dahlén, Gösta</creator><creator>Frick, M. Heikki</creator><creator>Krishan, Iqbal</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19760301</creationdate><title>Genetic Variation in Serum Low Density Lipoproteins and Lipid Levels in Man</title><author>Berg, Kåre ; Hames, Curtis ; Dahlén, Gösta ; Frick, M. Heikki ; Krishan, Iqbal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-3c64269c6f7b4fd211ab2632f1d0c3bdf1a140723e0851c95a5b138f9f50834f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Age Factors</topic><topic>Antigens</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Cholesterol - blood</topic><topic>Cholesterols</topic><topic>Genes</topic><topic>Genetic Variation</topic><topic>Humans</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Lipoproteins, LDL - blood</topic><topic>Lipoproteins, LDL - immunology</topic><topic>Medical genetics</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Population mean</topic><topic>Scandinavian and Nordic Countries</topic><topic>Serum cholesterol</topic><topic>T tests</topic><topic>Triglycerides</topic><topic>Triglycerides - blood</topic><topic>United States</topic><topic>White People</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berg, Kåre</creatorcontrib><creatorcontrib>Hames, Curtis</creatorcontrib><creatorcontrib>Dahlén, Gösta</creatorcontrib><creatorcontrib>Frick, M. Heikki</creatorcontrib><creatorcontrib>Krishan, Iqbal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berg, Kåre</au><au>Hames, Curtis</au><au>Dahlén, Gösta</au><au>Frick, M. Heikki</au><au>Krishan, Iqbal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Variation in Serum Low Density Lipoproteins and Lipid Levels in Man</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1976-03-01</date><risdate>1976</risdate><volume>73</volume><issue>3</issue><spage>937</spage><epage>940</epage><pages>937-940</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Combined data from 10 different populations indicate that the serum cholesterol and triglyceride levels are higher in Ag(x-) than in Ag(x+) individuals. Although the differences were relatively small, they became more pronounced with increasing age. The Ag(x) antigen, which is associated with the serum low density lipoprotein, is genetically controlled and the present study therefore has revealed a small but significant effect of a single autosomal locus on lipids implicated in the pathogenesis of atherosclerosis. No explanation of the higher cholesterol and triglyceride levels in Ag(x-) than in Ag (x+) persons is apparent.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>176662</pmid><doi>10.1073/pnas.73.3.937</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1976-03, Vol.73 (3), p.937-940 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmed_primary_176662 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Age Factors Antigens Black or African American Black People Cholesterol - blood Cholesterols Genes Genetic Variation Humans Lipids Lipoproteins Lipoproteins, LDL - blood Lipoproteins, LDL - immunology Medical genetics Phenotype Phenotypes Population mean Scandinavian and Nordic Countries Serum cholesterol T tests Triglycerides Triglycerides - blood United States White People |
| title | Genetic Variation in Serum Low Density Lipoproteins and Lipid Levels in Man |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T13%3A13%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20Variation%20in%20Serum%20Low%20Density%20Lipoproteins%20and%20Lipid%20Levels%20in%20Man&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Berg,%20K%C3%A5re&rft.date=1976-03-01&rft.volume=73&rft.issue=3&rft.spage=937&rft.epage=940&rft.pages=937-940&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.73.3.937&rft_dat=%3Cjstor_pubme%3E65542%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=83337816&rft_id=info:pmid/176662&rft_jstor_id=65542&rfr_iscdi=true |