Role of pharmacogenetics in chemotherapy of colorectal cancers

Clinical implications associated with polymorphisms in drug-metabolizing genes involved in the chemotherapy of colorectal cancers (5-flurorouracil, oxaliplatin and irinotecan) are reviewed. Treatments of colorectal cancers have been greatly improved last years but patients respond differently to ide...

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Veröffentlicht in:	La revue de medecine interne 2007-09, Vol.28 (9), p.594
Hauptverfasser:	Ceppa, F, Fontan, E, Cremades, S, Bihannic, R, Bousquet, A, Beauvillain, L, Burnat, P
Format:	Artikel
Sprache:	fre
Schlagworte:	Acetylcholinesterase - genetics Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Butyrylcholinesterase - genetics Camptothecin - adverse effects Camptothecin - analogs & derivatives Colorectal Neoplasms - drug therapy Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Dihydrouracil Dehydrogenase (NADP) - genetics Humans Methylenetetrahydrofolate Reductase (NADPH2) - genetics Organoplatinum Compounds - adverse effects Pharmacogenetics - methods Polymorphism, Genetic
Online-Zugang:	Volltext
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