Subclinical hypothyroidism in infertile women: The importance of continuous monitoring and the role of the thyrotropin-releasing hormone stimulation test
The aim of our study was to assess the prevalence of subclinical hypothyroidism (SH) after administering a thyrotropin-releasing hormone (TRH) stimulation test among women with normal serum thyroid-stimulating hormone (TSH) levels and various causes of infertility. Eighty-seven infertile women (39 w...
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| Veröffentlicht in: | Gynecological endocrinology 2007-06, Vol.23 (6), p.332-337 |
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| creator | Eldar-Geva, Talia Shoham, Michal Rösler, Ariel Margalioth, Ehud J. Livne, Keren Meirow, Dror |
| description | The aim of our study was to assess the prevalence of subclinical hypothyroidism (SH) after administering a thyrotropin-releasing hormone (TRH) stimulation test among women with normal serum thyroid-stimulating hormone (TSH) levels and various causes of infertility. Eighty-seven infertile women (39 with ovulation disorders and 48 with other causes of infertility) had a TRH stimulation test on day 3 - 7 of their cycle. Exaggerated TSH response (>30 mIU l at 20, 40 or 60 min) following intravenous injection of 400 µg TRH was defined as SH. The TRH test was performed 2 - 4 months after the first visit to the clinic. We found that the prevalence of SH was significantly higher among women with ovulation disorders (20.5%) than among women with normal ovulation (8.3%). In addition, we found that although basal TSH levels were normal at recruitment, 2 - 4 months later these levels were abnormally high in 8% of the women. All these women had an abnormal TRH test. We recommend performing TRH stimulation testing in women suffering from ovulation disorders who have normal basal TSH levels, followed by repeat assessments of thyroid function to enable treatment with thyroxine in cases with abnormal results. |
| doi_str_mv | 10.1080/09513590701267651 |
| format | Article |
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Eighty-seven infertile women (39 with ovulation disorders and 48 with other causes of infertility) had a TRH stimulation test on day 3 - 7 of their cycle. Exaggerated TSH response (>30 mIU l at 20, 40 or 60 min) following intravenous injection of 400 µg TRH was defined as SH. The TRH test was performed 2 - 4 months after the first visit to the clinic. We found that the prevalence of SH was significantly higher among women with ovulation disorders (20.5%) than among women with normal ovulation (8.3%). In addition, we found that although basal TSH levels were normal at recruitment, 2 - 4 months later these levels were abnormally high in 8% of the women. All these women had an abnormal TRH test. We recommend performing TRH stimulation testing in women suffering from ovulation disorders who have normal basal TSH levels, followed by repeat assessments of thyroid function to enable treatment with thyroxine in cases with abnormal results.</description><identifier>ISSN: 0951-3590</identifier><identifier>EISSN: 1473-0766</identifier><identifier>DOI: 10.1080/09513590701267651</identifier><identifier>PMID: 17616857</identifier><identifier>CODEN: GYENER</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; continuous monitoring ; dysovulation ; Female ; Humans ; Hypothyroidism - complications ; Hypothyroidism - diagnosis ; Hypothyroidism - epidemiology ; infertility ; Infertility, Female - blood ; Infertility, Female - complications ; Infertility, Female - physiopathology ; Injections, Intravenous ; Ovulation ; Population Surveillance ; Prevalence ; Prospective Studies ; Subclinical hypothyroidism ; Thyrotropin - blood ; Thyrotropin-Releasing Hormone - administration & dosage ; thyrotropin-releasing hormone stimulation test ; Time Factors</subject><ispartof>Gynecological endocrinology, 2007-06, Vol.23 (6), p.332-337</ispartof><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><rights>Copyright Taylor & Francis Ltd. Jun 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-8c1dc61a04f60074dc5622bdb2e5fd9641db9e5566d64fdf310151412cdd8caa3</citedby><cites>FETCH-LOGICAL-c431t-8c1dc61a04f60074dc5622bdb2e5fd9641db9e5566d64fdf310151412cdd8caa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09513590701267651$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09513590701267651$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17616857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eldar-Geva, Talia</creatorcontrib><creatorcontrib>Shoham, Michal</creatorcontrib><creatorcontrib>Rösler, Ariel</creatorcontrib><creatorcontrib>Margalioth, Ehud J.</creatorcontrib><creatorcontrib>Livne, Keren</creatorcontrib><creatorcontrib>Meirow, Dror</creatorcontrib><title>Subclinical hypothyroidism in infertile women: The importance of continuous monitoring and the role of the thyrotropin-releasing hormone stimulation test</title><title>Gynecological endocrinology</title><addtitle>Gynecol Endocrinol</addtitle><description>The aim of our study was to assess the prevalence of subclinical hypothyroidism (SH) after administering a thyrotropin-releasing hormone (TRH) stimulation test among women with normal serum thyroid-stimulating hormone (TSH) levels and various causes of infertility. Eighty-seven infertile women (39 with ovulation disorders and 48 with other causes of infertility) had a TRH stimulation test on day 3 - 7 of their cycle. Exaggerated TSH response (>30 mIU l at 20, 40 or 60 min) following intravenous injection of 400 µg TRH was defined as SH. The TRH test was performed 2 - 4 months after the first visit to the clinic. We found that the prevalence of SH was significantly higher among women with ovulation disorders (20.5%) than among women with normal ovulation (8.3%). In addition, we found that although basal TSH levels were normal at recruitment, 2 - 4 months later these levels were abnormally high in 8% of the women. All these women had an abnormal TRH test. We recommend performing TRH stimulation testing in women suffering from ovulation disorders who have normal basal TSH levels, followed by repeat assessments of thyroid function to enable treatment with thyroxine in cases with abnormal results.</description><subject>Adult</subject><subject>continuous monitoring</subject><subject>dysovulation</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothyroidism - complications</subject><subject>Hypothyroidism - diagnosis</subject><subject>Hypothyroidism - epidemiology</subject><subject>infertility</subject><subject>Infertility, Female - blood</subject><subject>Infertility, Female - complications</subject><subject>Infertility, Female - physiopathology</subject><subject>Injections, Intravenous</subject><subject>Ovulation</subject><subject>Population Surveillance</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Subclinical hypothyroidism</subject><subject>Thyrotropin - blood</subject><subject>Thyrotropin-Releasing Hormone - administration & dosage</subject><subject>thyrotropin-releasing hormone stimulation test</subject><subject>Time Factors</subject><issn>0951-3590</issn><issn>1473-0766</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc-K1TAUxoMoznX0AdxIcOGumtM2SatuZFBHGJjFjOuQJqnNkCY1SRnuo_i2pnMv-GdQCJxAft93cs6H0HMgr4F05A3pKTS0J5xAzTij8ADtoOVNRThjD9Fue6824AQ9SemGEGhaXj9GJ8AZsI7yHfpxtQ7KWW-VdHjaLyFP-xistmnG1pczmpitM_g2zMa_xdeTwXZeQszSK4PDiFXw2fo1rAnPwdscovXfsPQa58LG4O6o7X5nnWNYrK-icUamjZxCLDqDU7bz6mS2weNsUn6KHo3SJfPsWE_R108fr8_Oq4vLz1_OPlxUqm0gV50CrRhI0o6MEN5qRVldD3qoDR11z1rQQ28oZUyzdtRjAwQotFArrTslZXOKXh18lxi-r6WxmG1SxjnpTRlKcMJ62tG-gC__Am_CGn35m4Cet3VN-w2CA6RiSCmaUSzRzjLuBRCxhSbuhVY0L47G6zAb_UtxTKkA7w9AiaNsS96G6LTIcu9CHGMJwibR_M__3R_yyUiXJyWj-W2Cf6p_An6lu4c</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Eldar-Geva, Talia</creator><creator>Shoham, Michal</creator><creator>Rösler, Ariel</creator><creator>Margalioth, Ehud J.</creator><creator>Livne, Keren</creator><creator>Meirow, Dror</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Subclinical hypothyroidism in infertile women: The importance of continuous monitoring and the role of the thyrotropin-releasing hormone stimulation test</title><author>Eldar-Geva, Talia ; Shoham, Michal ; Rösler, Ariel ; Margalioth, Ehud J. ; Livne, Keren ; Meirow, Dror</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-8c1dc61a04f60074dc5622bdb2e5fd9641db9e5566d64fdf310151412cdd8caa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>continuous monitoring</topic><topic>dysovulation</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothyroidism - complications</topic><topic>Hypothyroidism - diagnosis</topic><topic>Hypothyroidism - epidemiology</topic><topic>infertility</topic><topic>Infertility, Female - blood</topic><topic>Infertility, Female - complications</topic><topic>Infertility, Female - physiopathology</topic><topic>Injections, Intravenous</topic><topic>Ovulation</topic><topic>Population Surveillance</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Subclinical hypothyroidism</topic><topic>Thyrotropin - blood</topic><topic>Thyrotropin-Releasing Hormone - administration & dosage</topic><topic>thyrotropin-releasing hormone stimulation test</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eldar-Geva, Talia</creatorcontrib><creatorcontrib>Shoham, Michal</creatorcontrib><creatorcontrib>Rösler, Ariel</creatorcontrib><creatorcontrib>Margalioth, Ehud J.</creatorcontrib><creatorcontrib>Livne, Keren</creatorcontrib><creatorcontrib>Meirow, Dror</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecological endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eldar-Geva, Talia</au><au>Shoham, Michal</au><au>Rösler, Ariel</au><au>Margalioth, Ehud J.</au><au>Livne, Keren</au><au>Meirow, Dror</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subclinical hypothyroidism in infertile women: The importance of continuous monitoring and the role of the thyrotropin-releasing hormone stimulation test</atitle><jtitle>Gynecological endocrinology</jtitle><addtitle>Gynecol Endocrinol</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>23</volume><issue>6</issue><spage>332</spage><epage>337</epage><pages>332-337</pages><issn>0951-3590</issn><eissn>1473-0766</eissn><coden>GYENER</coden><abstract>The aim of our study was to assess the prevalence of subclinical hypothyroidism (SH) after administering a thyrotropin-releasing hormone (TRH) stimulation test among women with normal serum thyroid-stimulating hormone (TSH) levels and various causes of infertility. Eighty-seven infertile women (39 with ovulation disorders and 48 with other causes of infertility) had a TRH stimulation test on day 3 - 7 of their cycle. Exaggerated TSH response (>30 mIU l at 20, 40 or 60 min) following intravenous injection of 400 µg TRH was defined as SH. The TRH test was performed 2 - 4 months after the first visit to the clinic. We found that the prevalence of SH was significantly higher among women with ovulation disorders (20.5%) than among women with normal ovulation (8.3%). In addition, we found that although basal TSH levels were normal at recruitment, 2 - 4 months later these levels were abnormally high in 8% of the women. All these women had an abnormal TRH test. We recommend performing TRH stimulation testing in women suffering from ovulation disorders who have normal basal TSH levels, followed by repeat assessments of thyroid function to enable treatment with thyroxine in cases with abnormal results.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>17616857</pmid><doi>10.1080/09513590701267651</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0951-3590 |
| ispartof | Gynecological endocrinology, 2007-06, Vol.23 (6), p.332-337 |
| issn | 0951-3590 1473-0766 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | Adult continuous monitoring dysovulation Female Humans Hypothyroidism - complications Hypothyroidism - diagnosis Hypothyroidism - epidemiology infertility Infertility, Female - blood Infertility, Female - complications Infertility, Female - physiopathology Injections, Intravenous Ovulation Population Surveillance Prevalence Prospective Studies Subclinical hypothyroidism Thyrotropin - blood Thyrotropin-Releasing Hormone - administration & dosage thyrotropin-releasing hormone stimulation test Time Factors |
| title | Subclinical hypothyroidism in infertile women: The importance of continuous monitoring and the role of the thyrotropin-releasing hormone stimulation test |
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